Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 174760..175292 Replicon chromosome
Accession NZ_CP049156
Organism Caballeronia sp. SBC1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SBC1_RS00810 Protein ID WP_165986937.1
Coordinates 174969..175292 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SBC1_RS00805 Protein ID WP_165085634.1
Coordinates 174760..174972 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC1_RS00780 170238..170738 - 501 WP_165986931.1 YbaK/EbsC family protein -
SBC1_RS00785 170770..171693 - 924 WP_165085623.1 hydroxymethylglutaryl-CoA lyase -
SBC1_RS00790 171762..172703 - 942 WP_165085625.1 glyoxylate/hydroxypyruvate reductase A -
SBC1_RS00795 172967..173587 + 621 WP_165986933.1 alpha/beta hydrolase -
SBC1_RS00800 173672..174679 + 1008 WP_165986935.1 sulfate ABC transporter substrate-binding protein -
SBC1_RS00805 174760..174972 + 213 WP_165085634.1 antitoxin MazE family protein Antitoxin
SBC1_RS00810 174969..175292 + 324 WP_165986937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SBC1_RS00815 175371..176432 - 1062 WP_165085639.1 biotin synthase BioB -
SBC1_RS00820 176468..177193 - 726 WP_165085641.1 dethiobiotin synthase -
SBC1_RS00825 177190..178410 - 1221 WP_165986938.1 8-amino-7-oxononanoate synthase -
SBC1_RS00830 178407..179795 - 1389 WP_165986940.1 adenosylmethionine--8-amino-7-oxononanoate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(6-69)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11808.74 Da        Isoelectric Point: 7.0147

>T150645 WP_165986937.1 NZ_CP049156:174969-175292 [Caballeronia sp. SBC1]
VRRGDLVTVSVQGNYGKPRPALIVQSDLFSEHGSVTVLLLTSELRDTPLFRVAIEPDEINQLSKRSQVMVDKAVTMPREK
LGEVFGRLEGELMISVNRAMAVFLGIA

Download         Length: 324 bp

>T150645 NZ_CP064855:726364-726783 [Erwinia amylovora]
GTGGTCCTGTGGCAATGTGAACTGCGGCCATCAAGGCTGGCACAGCGGTTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTATTGCCGACATGGCCCGCCAGCTCTGGCCTGGTGCGGATGCTGTTGCTGGTTTTGGTACTGTTGGAGTGCA
TACGCAGTCGGCGGCGCATTGGTCGTCGCCAGGGGGATATCGCTCTGTTGGAAGGGCATGAGCTACGCTGGCGTCAACGC
GAGTGGTGCATTATTTCCCGTCCGTGGCTGACCGGGCAGGCAATCCTGCTGTTACTACAGGATACTCATGGACAGCGCGA
GCGACTATGGCTGTTCGCCGACGGCATGGAAAAACGTAACTGGCGTCAGCTGCGCCTGCAATTGCTGAACAGTAAAGTAC
AGGGGAATGGCTGGTGCTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8173.26 Da        Isoelectric Point: 6.3275

>AT150645 WP_165085634.1 NZ_CP049156:174760-174972 [Caballeronia sp. SBC1]
MRQNVAERVGKRRAALRAAGLRPVQIWVPDTRREGFAEECRRQSLLLREDSQETEILDFIEASMDTKGWE

Download         Length: 213 bp

>AT150645 NZ_CP064855:726117-726383 [Erwinia amylovora]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAGCTGGATATCTCGATCATGCCCTT
TTTCCAGTATGAATTTGACTCGCTGAACGACAGCGATAAACGGCTGTTCGTTCGCCTGCTGGAGAGCGATGACCCGGACC
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGCAGACGTGGAGCTGAAAAGGATGGTGGCGCTAATCCAACAAAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References