Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1169097..1169716 Replicon chromosome
Accession NZ_CP049154
Organism Cronobacter sakazakii strain C105731

Toxin (Protein)


Gene name Hha Uniprot ID V5U1U2
Locus tag G4U59_RS05525 Protein ID WP_007781479.1
Coordinates 1169097..1169315 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag G4U59_RS05530 Protein ID WP_004386908.1
Coordinates 1169342..1169716 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4U59_RS05500 (G4U59_05470) 1165235..1167136 + 1902 WP_014729414.1 methyl-accepting chemotaxis protein -
G4U59_RS05505 (G4U59_05475) 1167275..1167535 + 261 WP_004386912.1 type B 50S ribosomal protein L31 -
G4U59_RS05510 (G4U59_05480) 1167539..1167679 + 141 WP_004386911.1 type B 50S ribosomal protein L36 -
G4U59_RS05515 (G4U59_05485) 1167708..1168217 - 510 WP_032989218.1 YlaC family protein -
G4U59_RS05520 (G4U59_05490) 1168337..1168888 - 552 WP_038881336.1 maltose O-acetyltransferase -
G4U59_RS05525 (G4U59_05495) 1169097..1169315 - 219 WP_007781479.1 HHA domain-containing protein Toxin
G4U59_RS05530 (G4U59_05500) 1169342..1169716 - 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
G4U59_RS05535 (G4U59_05505) 1170179..1173328 - 3150 WP_216296152.1 multidrug efflux RND transporter permease subunit AcrB -
G4U59_RS05540 (G4U59_05510) 1173350..1174555 - 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8614.02 Da        Isoelectric Point: 9.4828

>T150632 WP_007781479.1 NZ_CP049154:c1169315-1169097 [Cronobacter sakazakii]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T150632 NZ_CP064847:c4147485-4147108 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTCCGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAACATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT150632 WP_004386908.1 NZ_CP049154:c1169716-1169342 [Cronobacter sakazakii]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp

>AT150632 NZ_CP064847:c4147943-4147575 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGACGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V5U1U2

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References