Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 122051..123654 Replicon plasmid pCsaC79b
Accession NZ_CP049145
Organism Cronobacter sakazakii strain C79

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag G4U62_RS21255 Protein ID WP_148737327.1
Coordinates 122051..123370 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag G4U62_RS21260 Protein ID WP_148737325.1
Coordinates 123373..123654 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4U62_RS21245 (G4U62_21205) 117433..119964 - 2532 WP_148737329.1 malto-oligosyltrehalose synthase -
G4U62_RS21250 (G4U62_21210) 119961..121745 - 1785 WP_216310390.1 malto-oligosyltrehalose trehalohydrolase -
G4U62_RS21255 (G4U62_21215) 122051..123370 - 1320 WP_148737327.1 type II toxin-antitoxin system HipA family toxin Toxin
G4U62_RS21260 (G4U62_21220) 123373..123654 - 282 WP_148737325.1 helix-turn-helix domain-containing protein Antitoxin
G4U62_RS21265 (G4U62_21225) 123785..124669 - 885 WP_148737323.1 siderophore-interacting protein -
G4U62_RS21270 (G4U62_21230) 124666..125877 - 1212 WP_148737321.1 MFS transporter -
G4U62_RS21275 (G4U62_21235) 126013..127761 + 1749 WP_148737319.1 IucA/IucC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH / mgtB / iucA / iucB / iucC / iutA 1..137579 137579


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49011.00 Da        Isoelectric Point: 7.0031

>T150631 WP_148737327.1 NZ_CP049145:c123370-122051 [Cronobacter sakazakii]
MRRTSRLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVARTQMAQFEEQKVLVVERFDR
RLSADGQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTILSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRSGSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVIARVADALPVDFPASLADVIFNGMRQQCARLAAA

Download         Length: 1320 bp

>T150631 NZ_CP064847:c3915435-3915028 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10532.02 Da        Isoelectric Point: 9.0637

>AT150631 WP_148737325.1 NZ_CP049145:c123654-123373 [Cronobacter sakazakii]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQTAEADA
PARDDSPAHREAW

Download         Length: 282 bp

>AT150631 NZ_CP064847:c3915682-3915416 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References