Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3443834..3444467 Replicon chromosome
Accession NZ_CP049144
Organism Cronobacter sakazakii strain C79

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G4U62_RS16215 Protein ID WP_216309941.1
Coordinates 3443834..3444010 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G4U62_RS16220 Protein ID WP_216309943.1
Coordinates 3444060..3444467 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4U62_RS16195 (G4U62_16165) 3439387..3440990 + 1604 Protein_3158 DEAD/DEAH box helicase -
G4U62_RS16200 (G4U62_16170) 3440987..3441961 + 975 WP_216309935.1 toprim domain-containing protein -
G4U62_RS16205 (G4U62_16175) 3441961..3442821 + 861 WP_216309937.1 helix-turn-helix domain-containing protein -
G4U62_RS16210 (G4U62_16180) 3442818..3443621 + 804 WP_216309939.1 antitermination protein -
G4U62_RS16215 (G4U62_16185) 3443834..3444010 + 177 WP_216309941.1 type II toxin-antitoxin system HicA family toxin Toxin
G4U62_RS16220 (G4U62_16190) 3444060..3444467 + 408 WP_216309943.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G4U62_RS16225 (G4U62_16195) 3444559..3444939 + 381 WP_216309944.1 phage holin family protein -
G4U62_RS16230 (G4U62_16200) 3444926..3445210 + 285 WP_007709085.1 phage holin family protein -
G4U62_RS16235 (G4U62_16205) 3445207..3445830 + 624 WP_216309946.1 glycoside hydrolase family 19 protein -
G4U62_RS16240 (G4U62_16210) 3445830..3446300 + 471 WP_216309948.1 lysis protein -
G4U62_RS16245 (G4U62_16215) 3446345..3446542 + 198 WP_216309950.1 hypothetical protein -
G4U62_RS16250 (G4U62_16220) 3446615..3446800 - 186 WP_216309952.1 hypothetical protein -
G4U62_RS16255 (G4U62_16225) 3447006..3448463 + 1458 WP_216309954.1 glycosyltransferase family 2 protein -
G4U62_RS16260 (G4U62_16230) 3448445..3449035 + 591 WP_216309956.1 hypothetical protein -
G4U62_RS16265 (G4U62_16235) 3449066..3449359 - 294 WP_216309958.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3432703..3471472 38769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-131)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6675.77 Da        Isoelectric Point: 11.4650

>T150621 WP_216309941.1 NZ_CP049144:3443834-3444010 [Cronobacter sakazakii]
VKQSEFRRWLESQGVEVSNGTNHLKLKHNGKRSVMPRHPSAEIKESLRKAILKQLGLK

Download         Length: 177 bp

>T150621 NZ_CP064847:c1111577-1111035 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14656.70 Da        Isoelectric Point: 4.4731

>AT150621 WP_216309943.1 NZ_CP049144:3444060-3444467 [Cronobacter sakazakii]
MRYPVKLDPDSGGYFVSFPDIPEALTQGDSREEALAMALDALVTSFDFYFEDGRAVPDPSAVTDDFVEVPSSVAAKVILL
NTFLASGLTQVELAARMGIKKQEVTRLFDLHHSTKIDTIQKALAALGKTLELHAA

Download         Length: 408 bp

>AT150621 NZ_CP064847:c1111872-1111561 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References