Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1884807..1885326 Replicon chromosome
Accession NZ_CP049144
Organism Cronobacter sakazakii strain C79

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G4U62_RS08820 Protein ID WP_004385271.1
Coordinates 1885039..1885326 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G4U62_RS08815 Protein ID WP_004385270.1
Coordinates 1884807..1885049 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4U62_RS08800 (G4U62_08800) 1880850..1881968 + 1119 WP_216310284.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
G4U62_RS08805 (G4U62_08805) 1881965..1882705 + 741 WP_148736439.1 KDGP aldolase family protein -
G4U62_RS08810 (G4U62_08810) 1882819..1884729 + 1911 WP_148736438.1 PRD domain-containing protein -
G4U62_RS08815 (G4U62_08815) 1884807..1885049 + 243 WP_004385270.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G4U62_RS08820 (G4U62_08820) 1885039..1885326 + 288 WP_004385271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4U62_RS08825 (G4U62_08825) 1885334..1885798 - 465 WP_148736437.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
G4U62_RS08830 (G4U62_08830) 1885985..1888120 - 2136 WP_097582651.1 anaerobic ribonucleoside-triphosphate reductase -
G4U62_RS08835 (G4U62_08835) 1888417..1889298 - 882 WP_007871040.1 LysR family transcriptional regulator -
G4U62_RS08840 (G4U62_08840) 1889401..1889931 + 531 WP_148736436.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10811.80 Da        Isoelectric Point: 10.5836

>T150617 WP_004385271.1 NZ_CP049144:1885039-1885326 [Cronobacter sakazakii]
MSYKLVFDPRALKEWHKLGETVKAQFKKKLAHVLAAPRVKSARLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAGHRLE

Download         Length: 288 bp

>T150617 NZ_CP064847:492251-492541 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACTGGGATATCGCCTGGTCTATTCCGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAAAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9037.45 Da        Isoelectric Point: 5.1088

>AT150617 WP_004385270.1 NZ_CP049144:1884807-1885049 [Cronobacter sakazakii]
MATINVRLDDKLKNEAYAVLEKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPRPGIRVDLDEL

Download         Length: 243 bp

>AT150617 NZ_CP064847:492019-492261 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATTACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References