150614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 5616502..5617049 Replicon chromosome
Accession NZ_CP049140
Organism Pseudomonas nitroreducens strain HBP1

Toxin (Protein)


Gene name parE Uniprot ID A0A6G6J352
Locus tag G5B91_RS26965 Protein ID WP_024762619.1
Coordinates 5616762..5617049 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0F0DTW6
Locus tag G5B91_RS26960 Protein ID WP_024762620.1
Coordinates 5616502..5616771 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5B91_RS26935 5611680..5612807 - 1128 WP_024762624.1 GGDEF domain-containing protein -
G5B91_RS26940 5613060..5614583 + 1524 WP_024762623.1 fumarate hydratase -
G5B91_RS26945 5614715..5615017 - 303 WP_017519692.1 ribbon-helix-helix domain-containing protein -
G5B91_RS26950 5615051..5615632 - 582 WP_024762622.1 DJ-1/PfpI family protein -
G5B91_RS26955 5615736..5616314 - 579 WP_024762621.1 DUF2846 domain-containing protein -
G5B91_RS26960 5616502..5616771 + 270 WP_024762620.1 ribbon-helix-helix protein, CopG family Antitoxin
G5B91_RS26965 5616762..5617049 + 288 WP_024762619.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5B91_RS26970 5617057..5617644 - 588 WP_024762618.1 hypothetical protein -
G5B91_RS26975 5617828..5619120 - 1293 WP_024762617.1 acyltransferase -
G5B91_RS26980 5619155..5620312 - 1158 WP_024762616.1 cardiolipin synthase B -
G5B91_RS26985 5620309..5620884 - 576 WP_024762615.1 YceI family protein -
G5B91_RS26990 5620996..5621901 - 906 WP_024762614.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10925.54 Da        Isoelectric Point: 8.4752

>T150614 WP_024762619.1 NZ_CP049140:5616762-5617049 [Pseudomonas nitroreducens]
MRVIYAPAALRDLDRLRRFLRETNPTAARRAGQIILQATQALGAYPQMGRLIDDLPIEFREWPIDFGDSGYIARYHIDGE
TLVILAIRHQREAGY

Download         Length: 288 bp

>T150614 NZ_CP064847:302677-302850 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10472.62 Da        Isoelectric Point: 4.4422

>AT150614 WP_024762620.1 NZ_CP049140:5616502-5616771 [Pseudomonas nitroreducens]
MATSVKLDEEMLARVRELAELRQRSPHWIMREAIGQYVVREEQREKLKRDTEQAWEEFQATGQHVTAEAVESWLNSWGDE
DEQAAPKCE

Download         Length: 270 bp

>AT150614 NZ_CP064847:302353-302649 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6J352

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0DTW6

References