Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5091005..5091601 Replicon chromosome
Accession NZ_CP049140
Organism Pseudomonas nitroreducens strain HBP1

Toxin (Protein)


Gene name PfiT Uniprot ID A0A6G6J1I8
Locus tag G5B91_RS24330 Protein ID WP_024763400.1
Coordinates 5091005..5091346 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A6G6J1L4
Locus tag G5B91_RS24335 Protein ID WP_024763399.1
Coordinates 5091353..5091601 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5B91_RS24290 5086138..5086437 + 300 WP_024763406.1 hypothetical protein -
G5B91_RS24295 5086883..5087647 - 765 WP_065085981.1 RES family NAD+ phosphorylase -
G5B91_RS24300 5087648..5088016 - 369 WP_024763405.1 DUF2384 domain-containing protein -
G5B91_RS24305 5088286..5088777 + 492 WP_024763404.1 RcnB family protein -
G5B91_RS24310 5088784..5089215 - 432 WP_024763403.1 hypothetical protein -
G5B91_RS24315 5089340..5089822 + 483 WP_024763402.1 GreA/GreB family elongation factor -
G5B91_RS24320 5089956..5090303 + 348 WP_017522075.1 carboxymuconolactone decarboxylase family protein -
G5B91_RS24325 5090373..5090771 + 399 WP_128082500.1 hypothetical protein -
G5B91_RS24330 5091005..5091346 - 342 WP_024763400.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5B91_RS24335 5091353..5091601 - 249 WP_024763399.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G5B91_RS24340 5091702..5092976 - 1275 WP_024763398.1 hypothetical protein -
G5B91_RS24345 5093218..5094507 - 1290 WP_038803301.1 hypothetical protein -
G5B91_RS24350 5094511..5094867 - 357 WP_024763397.1 DUF2523 domain-containing protein -
G5B91_RS24355 5094871..5095818 - 948 WP_051445584.1 hypothetical protein -
G5B91_RS24360 5096325..5096564 - 240 WP_024763395.1 major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12976.64 Da        Isoelectric Point: 4.5106

>T150613 WP_024763400.1 NZ_CP049140:c5091346-5091005 [Pseudomonas nitroreducens]
MTAREIRFTETAVFSIQDQEEHLADYHPPELAAAKIDGLIDEILTRLQDAPVGYPVSRQASDLGVTRYRELNHDGYRVFY
EVYEHENVIAVELVLRQKQDVEAALIRYCLVGI

Download         Length: 342 bp

>T150613 NZ_CP064837:38684-39580 [Lactococcus lactis subsp. lactis]
ATGAAAAATACAAGGTTAAAGGATTTAATTGCAACAAGAAATGATGATATTGGAATTGAAAATTATAGAATAAGATATGC
AACTGAAAGATTCTTAACAAGGCTTTCGGCAAGTCAATATAAGGAAAAATTTGTTTTAAAAGGAGGTTTTTTAATTGGTG
TCACCTATAACTTGAGTCAGAGGACTACTAAGGATTTAGATACAGCTCTGATAGACTTTAAAAGTGATGCACAGTCTATT
GAACGGGTAATTACTGAAATATGTAATATAGATTTAGAAGACCAAGTGCTTTTTAAATTAAAGGAACTTACAAGCAGTCA
AGATATGAGAATATATCCTGGGTACAGAGCTAAACTTAAGATGATGTTTCCTGATGGAAATACAAGGATAGACTTTGATC
TTGATATTGGAGTAGGAGATAGGATAACCCCAGAGGCTAAGAAAATAAAAATACCTCTAATATTTAATGAAGTAAAAGGT
GTAGAGAAACAGATAGAAGTATTAGCTTATCCAAAAGAAACTATTCAGGCAGAAAAATTAGAGACAATTCTCACTCGGGG
GAAAGTAAATACTAGAATGAAAGATTATTACGATTTTCATTTGCTTTTGACTGATCAAGAAAATAGTAATAGTATAAGTT
TTTATTATGCTTTTAAAAATACTTGGGAATTTAGAAACCCAACTCAATTTATTGATGAAGAACTGTTTGAAGATTGGCTC
TTTATTTTAGATGAGATACTTGAATCAAAAGAATTGAAAGAAAAGTATTGGCCAAACTATATTAAAGATAGAAATTATGC
TAAACATCTAAACATGGATGATATCATTTCAGAAATTAAAGAATTTGTTAGTAAATTAAAAGAAGAATATATAAAGGAGA
ATATGTCTAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9312.72 Da        Isoelectric Point: 9.5977

>AT150613 WP_024763399.1 NZ_CP049140:c5091601-5091353 [Pseudomonas nitroreducens]
MRVETISYLKRHAADLDLDEPMVVTQNGVPTLVVESYAERKRRDQAIALVKLLAMGSREYAEGKHCSADELKARLAKRRS
QQ

Download         Length: 249 bp

>AT150613 NZ_CP064837:37824-38687 [Lactococcus lactis subsp. lactis]
ATGGACACTTATAGAATATCAAACTTAAATCTAGAACAGGAAGATATAAATAATCTAAAGAGAATCTCAACCAATATGTT
AGATACTTTTAACCATGAACAGCTTCTTTCAATCATTGATGTGATGAAAAATACTTATTTCATGAATGAACTCTCAACCT
ATTTAGTAGACGATAATCTCCCTGATGTAGGTACTGAAGAATTTAATTTTTTGGTTCTTGCTAATAAATATAAAGGAAAT
ATAATAAGAAAAATAGTACGTGATGAAGGTATAAGTGATTACTATTTGAGAAAATTTGTTTTGAAGTATAATCTTACTGA
GGTTGACAAAGGTGTTTATATTTTTCCTCATAAAAAAAAGGACAGTTTATTTATTTTTCAGCAGAAATACAGCAAAGCAG
TTATCTCACATGAAACATCATTATATCTACAAGATGTAATAGATTATATTCCGCAAAAAATACAAATGAGCGTTCCAGAA
AAGTATAATATCAGTAGAATTCAGGAACCTCACGAAAATCGTTTAACAAGCTATAACTATGTGGATATTAACTCTAATAA
TATAATGGATAAAAATATTCCAATCAATTTAGTCAGAAATAAGAGTATTAGTCCTACACAAATAGAAACAGTAAATAGCT
TTTTAGGTCTCCCACTAAGAGTCACTTCTATTGCTCGGTCGATAGTAGACGTTTTAAAACCTTCCCACAAGGCTGAAGAA
GAAGTGAAAGAACAGGCGATTAAGTATTATTTAGAAAGATTTCCAGATAATATTGTGCGCTTAAAACGTATAGCTAAAAC
ACAAAATGTTTTAAAAGAACTAGAGTATTACTTGATTTTATTGGGAGTACATTATAAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6J1I8

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6J1L4

References