Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 5086883..5088016 | Replicon | chromosome |
| Accession | NZ_CP049140 | ||
| Organism | Pseudomonas nitroreducens strain HBP1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A1B8SZD5 |
| Locus tag | G5B91_RS24295 | Protein ID | WP_065085981.1 |
| Coordinates | 5086883..5087647 (-) | Length | 255 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A1B8V7T7 |
| Locus tag | G5B91_RS24300 | Protein ID | WP_024763405.1 |
| Coordinates | 5087648..5088016 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G5B91_RS24275 | 5082293..5083183 | + | 891 | WP_024763408.1 | metal-dependent hydrolase | - |
| G5B91_RS24280 | 5083272..5084618 | + | 1347 | WP_024763407.1 | FAD-binding oxidoreductase | - |
| G5B91_RS24285 | 5084661..5086025 | - | 1365 | WP_037006803.1 | DNA recombination protein RmuC | - |
| G5B91_RS24290 | 5086138..5086437 | + | 300 | WP_024763406.1 | hypothetical protein | - |
| G5B91_RS24295 | 5086883..5087647 | - | 765 | WP_065085981.1 | RES family NAD+ phosphorylase | Toxin |
| G5B91_RS24300 | 5087648..5088016 | - | 369 | WP_024763405.1 | DUF2384 domain-containing protein | Antitoxin |
| G5B91_RS24305 | 5088286..5088777 | + | 492 | WP_024763404.1 | RcnB family protein | - |
| G5B91_RS24310 | 5088784..5089215 | - | 432 | WP_024763403.1 | hypothetical protein | - |
| G5B91_RS24315 | 5089340..5089822 | + | 483 | WP_024763402.1 | GreA/GreB family elongation factor | - |
| G5B91_RS24320 | 5089956..5090303 | + | 348 | WP_017522075.1 | carboxymuconolactone decarboxylase family protein | - |
| G5B91_RS24325 | 5090373..5090771 | + | 399 | WP_128082500.1 | hypothetical protein | - |
| G5B91_RS24330 | 5091005..5091346 | - | 342 | WP_024763400.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| G5B91_RS24335 | 5091353..5091601 | - | 249 | WP_024763399.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| G5B91_RS24340 | 5091702..5092976 | - | 1275 | WP_024763398.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 255 a.a. Molecular weight: 28877.06 Da Isoelectric Point: 8.4428
>T150612 WP_065085981.1 NZ_CP049140:c5087647-5086883 [Pseudomonas nitroreducens]
MSFEAGARLWAKYEDSVVAPIRGRLVRLVESQGQVATLQLVDTLEEQALLEELLETSKPRMPSSAEPLHYLLKTPFRYPP
LRWGSRFGRRHEPSLFYGALKLETAMAESAFYRFVLWEGMATPPPSGRILSEHASFEARFQVQKGVRLHLPPFREHAALL
DPQDYSVTQGMGSAMRDAGVEAFEYRSARCPQGGINVALFVPSAFTEKRPRNLMPWLCETTSEYVAFKHAQVPDSPRIYR
REQYLVDGRLPHPA
MSFEAGARLWAKYEDSVVAPIRGRLVRLVESQGQVATLQLVDTLEEQALLEELLETSKPRMPSSAEPLHYLLKTPFRYPP
LRWGSRFGRRHEPSLFYGALKLETAMAESAFYRFVLWEGMATPPPSGRILSEHASFEARFQVQKGVRLHLPPFREHAALL
DPQDYSVTQGMGSAMRDAGVEAFEYRSARCPQGGINVALFVPSAFTEKRPRNLMPWLCETTSEYVAFKHAQVPDSPRIYR
REQYLVDGRLPHPA
Download Length: 765 bp
>T150612 NZ_CP064833:c3846318-3845812 [Morganella morganii subsp. morganii]
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAA
ATTCCGGTTATCCTGCCGGGACGTCTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCGGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGCATCTATTCTGAATAG
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAA
ATTCCGGTTATCCTGCCGGGACGTCTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCGGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGCATCTATTCTGAATAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13515.77 Da Isoelectric Point: 10.1440
>AT150612 WP_024763405.1 NZ_CP049140:c5088016-5087648 [Pseudomonas nitroreducens]
MSALLKENPAADTVLAKAVLTAREHLAMTQQELAAIVGVDRSAVSRWKQNGLRVDSKTGELALLLVRIYRALFALFGGNH
EDMRHFLRTENRHLGGVPLQLMERVQGLVAVVEYLDAIRGKV
MSALLKENPAADTVLAKAVLTAREHLAMTQQELAAIVGVDRSAVSRWKQNGLRVDSKTGELALLLVRIYRALFALFGGNH
EDMRHFLRTENRHLGGVPLQLMERVQGLVAVVEYLDAIRGKV
Download Length: 369 bp
>AT150612 NZ_CP064833:c3846629-3846321 [Morganella morganii subsp. morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGGCGAAGGCGCCGTGGGAGAAGTAA
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGGCGAAGGCGCCGTGGGAGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B8SZD5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B8V7T7 |