Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 89731..90236 | Replicon | chromosome |
Accession | NZ_CP049140 | ||
Organism | Pseudomonas nitroreducens strain HBP1 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A1B8TFU7 |
Locus tag | G5B91_RS00425 | Protein ID | WP_024763697.1 |
Coordinates | 89731..90012 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1B8V0Q7 |
Locus tag | G5B91_RS00430 | Protein ID | WP_024763698.1 |
Coordinates | 90009..90236 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G5B91_RS00400 | 85632..86582 | + | 951 | WP_024763692.1 | alpha/beta hydrolase | - |
G5B91_RS00405 | 86677..87684 | + | 1008 | WP_081753981.1 | AraC family transcriptional regulator | - |
G5B91_RS00410 | 87686..88141 | - | 456 | WP_024763694.1 | GNAT family N-acetyltransferase | - |
G5B91_RS00415 | 88185..89102 | - | 918 | WP_024763695.1 | LysR family transcriptional regulator | - |
G5B91_RS00420 | 89200..89487 | + | 288 | WP_024763696.1 | DUF2218 domain-containing protein | - |
G5B91_RS00425 | 89731..90012 | - | 282 | WP_024763697.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
G5B91_RS00430 | 90009..90236 | - | 228 | WP_024763698.1 | CopG family ribbon-helix-helix protein | Antitoxin |
G5B91_RS00435 | 90477..91862 | + | 1386 | WP_038803461.1 | sodium:solute symporter | - |
G5B91_RS00440 | 91890..92846 | + | 957 | WP_024763699.1 | agmatinase | - |
G5B91_RS00445 | 92922..93848 | + | 927 | WP_024763700.1 | LysR family transcriptional regulator | - |
G5B91_RS00450 | 93845..94558 | + | 714 | WP_024763701.1 | phytanoyl-CoA dioxygenase family protein | - |
G5B91_RS00455 | 94574..94975 | + | 402 | WP_024763702.1 | GFA family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10323.76 Da Isoelectric Point: 5.6558
>T150608 WP_024763697.1 NZ_CP049140:c90012-89731 [Pseudomonas nitroreducens]
MSLQWTHKAAADLDAIYDHYVVLIGPEKALRAIQDIVEQVSPLANLDLSSSGVPSEVPGVRELSVERWPYQAAFRVKGRS
VQILRIDRVDNPG
MSLQWTHKAAADLDAIYDHYVVLIGPEKALRAIQDIVEQVSPLANLDLSSSGVPSEVPGVRELSVERWPYQAAFRVKGRS
VQILRIDRVDNPG
Download Length: 282 bp
>T150608 NZ_CP064832:c895582-895379 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8245.19 Da Isoelectric Point: 5.9478
>AT150608 WP_024763698.1 NZ_CP049140:c90236-90009 [Pseudomonas nitroreducens]
VTTVVSFRADDSLVAALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGVADADAGHLLEHAAIEGKWGLA
VTTVVSFRADDSLVAALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGVADADAGHLLEHAAIEGKWGLA
Download Length: 228 bp
>AT150608 NZ_CP064832:c896005-895646 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1B8TFU7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1B8V0Q7 |