Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 89731..90236 Replicon chromosome
Accession NZ_CP049140
Organism Pseudomonas nitroreducens strain HBP1

Toxin (Protein)


Gene name parE Uniprot ID A0A1B8TFU7
Locus tag G5B91_RS00425 Protein ID WP_024763697.1
Coordinates 89731..90012 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B8V0Q7
Locus tag G5B91_RS00430 Protein ID WP_024763698.1
Coordinates 90009..90236 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5B91_RS00400 85632..86582 + 951 WP_024763692.1 alpha/beta hydrolase -
G5B91_RS00405 86677..87684 + 1008 WP_081753981.1 AraC family transcriptional regulator -
G5B91_RS00410 87686..88141 - 456 WP_024763694.1 GNAT family N-acetyltransferase -
G5B91_RS00415 88185..89102 - 918 WP_024763695.1 LysR family transcriptional regulator -
G5B91_RS00420 89200..89487 + 288 WP_024763696.1 DUF2218 domain-containing protein -
G5B91_RS00425 89731..90012 - 282 WP_024763697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5B91_RS00430 90009..90236 - 228 WP_024763698.1 CopG family ribbon-helix-helix protein Antitoxin
G5B91_RS00435 90477..91862 + 1386 WP_038803461.1 sodium:solute symporter -
G5B91_RS00440 91890..92846 + 957 WP_024763699.1 agmatinase -
G5B91_RS00445 92922..93848 + 927 WP_024763700.1 LysR family transcriptional regulator -
G5B91_RS00450 93845..94558 + 714 WP_024763701.1 phytanoyl-CoA dioxygenase family protein -
G5B91_RS00455 94574..94975 + 402 WP_024763702.1 GFA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10323.76 Da        Isoelectric Point: 5.6558

>T150608 WP_024763697.1 NZ_CP049140:c90012-89731 [Pseudomonas nitroreducens]
MSLQWTHKAAADLDAIYDHYVVLIGPEKALRAIQDIVEQVSPLANLDLSSSGVPSEVPGVRELSVERWPYQAAFRVKGRS
VQILRIDRVDNPG

Download         Length: 282 bp

>T150608 NZ_CP064832:c895582-895379 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8245.19 Da        Isoelectric Point: 5.9478

>AT150608 WP_024763698.1 NZ_CP049140:c90236-90009 [Pseudomonas nitroreducens]
VTTVVSFRADDSLVAALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGVADADAGHLLEHAAIEGKWGLA

Download         Length: 228 bp

>AT150608 NZ_CP064832:c896005-895646 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B8TFU7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8V0Q7

References