Detailed information of TA system TA150604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1740828..1742563
• Replicon: chromosome
• Accession: NZ_CP049139
• Organism: Herbaspirillum frisingense strain IAC152

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: G5S34_RS07780
• Protein ID: WP_182994282.1
• Coordinates: 1740828..1741715 (+)
• Length: 296 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1V2VDX6
• Locus tag: G5S34_RS07785
• Protein ID: WP_006462350.1
• Coordinates: 1741730..1742563 (+)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5S34_RS07755	1736700..1737485	+	786	WP_006462344.1	ABC transporter ATP-binding protein	-
G5S34_RS07760	1737541..1738536	+	996	WP_006462345.1	ABC transporter substrate-binding protein	-
G5S34_RS07765	1738539..1739408	+	870	WP_182994280.1	ABC transporter permease	-
G5S34_RS07770	1739445..1740215	+	771	WP_039874635.1	SDR family oxidoreductase	-
G5S34_RS07775	1740274..1740810	+	537	WP_182994281.1	cupin domain-containing protein	-
G5S34_RS07780	1740828..1741715	+	888	WP_182994282.1	alpha/beta hydrolase	Toxin
G5S34_RS07785	1741730..1742563	+	834	WP_006462350.1	IclR family transcriptional regulator	Antitoxin
G5S34_RS07790	1742565..1743389	+	825	WP_039874641.1	SDR family oxidoreductase	-
G5S34_RS07795	1743382..1745121	+	1740	WP_182994283.1	thiamine pyrophosphate-binding protein	-
G5S34_RS07800	1745132..1745932	+	801	WP_182994284.1	aspartate dehydrogenase	-
G5S34_RS07805	1745982..1747457	+	1476	WP_174616894.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-279)

Antitoxin

• Transcription regulator IclR, N-terminal (20-68)

Sequences

Toxin

Protein

• Length: 296 a.a.
• Molecular weight: 31295.63 Da
• Isoelectric Point: 6.7524

>T150604 WP_182994282.1 NZ_CP049139:1740828-1741715 [Herbaspirillum frisingense]
MHPHTSIASATAVSCDDALREPLALLEGRFAEGSVEVPGGRVSYRSCGSGPVVVLLHGISSGAASWLQCALKLESQARVI
AWNAPGYGRSTPLTMSQPKAVDYAGRLQDMLLALEVEQCVLVGHSLGALMAAAYLAHGDGRARRTLLADPALGYGAASKQ
ERAHQVREERLGALRTLGIAGMAQKPTRLLSAHASVQDHAWVRWNMQWLDASGYTQAVQLLCGDDIAPYLQAAPRRGLSV
ACGAEDIVTTPEASEGLARQFELPFKLVDAAGHACYIEQPSQFAALISAQLTSTN

Nucleotide

• Length: 888 bp

>T150604 NZ_CP064829:c3779348-3778842 [Morganella morganii subsp. morganii]
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGTGTTATTACCTGTTCACAGGCGGCGGGACGCTTCAGACGTAATATGCCTCCGGAA
ATTCCGGTTATTCTGCCGGGACGTCTTGCTGTTGATGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCAGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATACCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGTATCTATTCTGAATAG

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30744.22 Da
• Isoelectric Point: 6.2489

>AT150604 WP_006462350.1 NZ_CP049139:1741730-1742563 [Herbaspirillum frisingense]
MNKPVMPEEESQDKYSVPGLERGLRLLCEFSRQDKTLSAPELARRLDIPRSTVFRLLATLERMGFVERADGGRDYRLGMS
VLRLGFEYLASLELTEIGRPLLDRLRDEIGYSCNLVVRDGRSIVYVAKSVTQTAFTSHVNVGTRLPAHATVLGRVLLEDL
SLPQLRALYPEEHLEVFSSNTPKTVVELFDMVQADKERGFVLQEGFFETSISTVAAPVRDHSGNVVAAMGATIPSPHIDA
SQLDIIVARVRDTAAELSRLLDHAPQGGAKVVNMWRG

Nucleotide

• Length: 834 bp

>AT150604 NZ_CP064829:c3779659-3779351 [Morganella morganii subsp. morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1V2VDX6