Detailed information of TA system TA150602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 86014..86537
• Replicon: chromosome
• Accession: NZ_CP049138
• Organism: Paraburkholderia tropica strain IAC135

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G5S35_RS37475
• Protein ID: WP_202035078.1
• Coordinates: 86283..86537 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1H7ER32
• Locus tag: G5S35_RS37470
• Protein ID: WP_074987081.1
• Coordinates: 86014..86274 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5S35_RS37430	81025..83346	+	2322	WP_110329935.1	SMC family ATPase	-
G5S35_RS37435	83420..83602	+	183	WP_110329936.1	hypothetical protein	-
G5S35_RS37440	83657..83857	+	201	WP_110329937.1	hypothetical protein	-
G5S35_RS37445	84107..84463	+	357	WP_110329938.1	hypothetical protein	-
G5S35_RS37450	84474..84796	+	323	Protein_70	winged helix-turn-helix transcriptional regulator	-
G5S35_RS37455	84937..85299	+	363	WP_183040822.1	hypothetical protein	-
G5S35_RS37460	85431..85616	+	186	WP_074987079.1	hypothetical protein	-
G5S35_RS37465	85635..85901	+	267	WP_074987080.1	hypothetical protein	-
G5S35_RS37470	86014..86274	+	261	WP_074987081.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G5S35_RS37475	86283..86537	+	255	WP_202035078.1	Txe/YoeB family addiction module toxin	Toxin
G5S35_RS37480	86846..87448	+	603	WP_110329939.1	hypothetical protein	-
G5S35_RS37485	87590..88024	+	435	WP_124263228.1	hypothetical protein	-
G5S35_RS37490	88058..88513	+	456	WP_161495523.1	hypothetical protein	-
G5S35_RS37495	88652..88858	+	207	WP_074987085.1	hypothetical protein	-
G5S35_RS37500	88884..89204	+	321	WP_183040823.1	hypothetical protein	-
G5S35_RS37505	89640..89939	+	300	WP_074987088.1	hypothetical protein	-
G5S35_RS37510	89952..90098	+	147	WP_161495522.1	hypothetical protein	-
G5S35_RS37515	90172..90450	-	279	WP_074987089.1	H-NS histone family protein	-
G5S35_RS37520	90600..91067	-	468	WP_183040824.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10138.49 Da
• Isoelectric Point: 7.9846

>T150602 WP_202035078.1 NZ_CP049138:86283-86537 [Paraburkholderia tropica]
MNIMWTAEAWDDYVYWQGQDKKTLRRINQLIKDVQRSPFEGIGKPEPLKENLTGFWSRRIDETNRLVYEVANTQINIVSC
RYHY

Nucleotide

• Length: 255 bp

>T150602 NZ_CP064829:c973998-973795 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9618.98 Da
• Isoelectric Point: 6.7245

>AT150602 WP_074987081.1 NZ_CP049138:86014-86274 [Paraburkholderia tropica]
MRTIPFTDARANLKRVIDQVVDDVDVTLITRRDAPNAVVMSQEHYDSLMETVHLLRSPANVAHLERSIAQARAGKVKPRA
LVDDAE

Nucleotide

• Length: 261 bp

>AT150602 NZ_CP064829:c974421-974062 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA

Structures

Antitoxin

• AlphaFold DB: A0A1H7ER32