Detailed information of TA system TA150601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 540249..542044
• Replicon: chromosome
• Accession: NZ_CP049137
• Organism: Paraburkholderia tropica strain IAC135

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: G5S35_RS32935
• Protein ID: WP_124261587.1
• Coordinates: 541148..542044 (-)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1A5XLJ1
• Locus tag: G5S35_RS32930
• Protein ID: WP_065057806.1
• Coordinates: 540249..541133 (-)
• Length: 295 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5S35_RS32910	535374..536867	-	1494	WP_065057810.1	aldehyde dehydrogenase	-
G5S35_RS32915	536957..537790	-	834	WP_065057809.1	aspartate dehydrogenase	-
G5S35_RS32920	537783..539441	-	1659	WP_065057808.1	thiamine pyrophosphate-binding protein	-
G5S35_RS32925	539434..540252	-	819	WP_110326540.1	SDR family oxidoreductase	-
G5S35_RS32930	540249..541133	-	885	WP_065057806.1	IclR family transcriptional regulator	Antitoxin
G5S35_RS32935	541148..542044	-	897	WP_124261587.1	alpha/beta hydrolase	Toxin
G5S35_RS32940	542096..542632	-	537	WP_065057902.1	cupin domain-containing protein	-
G5S35_RS32945	542691..543446	-	756	WP_065057805.1	SDR family oxidoreductase	-
G5S35_RS32950	543484..544569	-	1086	WP_065057804.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
G5S35_RS32955	544607..544918	-	312	WP_065057803.1	hypothetical protein	-
G5S35_RS32960	544920..545234	-	315	WP_065057802.1	non-heme iron oxygenase ferredoxin subunit	-
G5S35_RS32965	545687..546760	+	1074	WP_074986604.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (55-283)

Antitoxin

• Transcription regulator IclR, C-terminal (144-268)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 31019.15 Da
• Isoelectric Point: 6.2172

>T150601 WP_124261587.1 NZ_CP049137:c542044-541148 [Paraburkholderia tropica]
MNDAMLTDASSAATLDTLDTRLARFAPRHVQAGEAVVSYRAAPGAGSEDGNEALPLVLLHGIGSGAASWVQQMETLGASR
RVIAWDAPGYGASTPVANASPLAADYARVLADWLDALDIQRCVLVGHSLGAIIAGAFAAAHPQRVSGLLLISPAAGYGAA
DPQVRADKRDARLAMLADLGPQGLAEKRSANMLSAHADDASRAWVRWNMARVLPHGYAQATHLLANADLAADLARCVNRV
PMAVAVGADDTITPPQACERLAQVAQAPFQIVPQAGHAGYIEQPAAYSALLDAFCRAH

Nucleotide

• Length: 897 bp

>T150601 NZ_CP064828:c3740878-3740531 [Morganella morganii subsp. morganii]
ATGGCCTATTATGCATTATCGACAGGTGTTATTACCTGTTCACAGGCGGCGGGACGCTTCAGACGTAATATGCCTCCGGA
AATTCCGGTTATTCTGCCGGGACGTCTTGCTGTTGATGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAG
ATGCCGCACTGCGGGTCTTGCAGGCAGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCC
AGACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCA
GCTGGCAACCGGTATCTATTCTGAATAG

Antitoxin

Protein

• Length: 295 a.a.
• Molecular weight: 32264.60 Da
• Isoelectric Point: 6.3641

>AT150601 WP_065057806.1 NZ_CP049137:c541133-540249 [Paraburkholderia tropica]
MTPDLASASPDADEDRNDTSYRVPGLERGLRILTEFSPREPVLDAPELSRRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEALRDATGLTTHIVIRDGRDIVFVAKAQSHAPIFSSVKVNVGTRLPAHATTH
GQVLMGDLTLDELRALYPEPALERFTPSTPDTVEELFARIREDAERGYAVSESSFERGISVVSAPVRNDTGRIAAVVTTT
IPRPGIDTSLLDGGLIDKVRHAADELSKRLNYRGQSSQAAGSKKTSYMKALGIK

Nucleotide

• Length: 885 bp

>AT150601 NZ_CP064828:c3741183-3740878 [Morganella morganii subsp. morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A1A5XLJ1