Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 269803..271622 Replicon chromosome
Accession NZ_CP049135
Organism Paraburkholderia tropica strain IAC135

Toxin (Protein)


Gene name hipA Uniprot ID A0A1A5X0M3
Locus tag G5S35_RS15945 Protein ID WP_065065753.1
Coordinates 269803..271134 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1A5WZK2
Locus tag G5S35_RS15950 Protein ID WP_065065764.1
Coordinates 271134..271622 (-) Length 163 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S35_RS15925 265118..266239 - 1122 WP_124261977.1 helix-turn-helix domain-containing protein -
G5S35_RS15930 266582..267718 - 1137 WP_110328175.1 NAD(P)-dependent alcohol dehydrogenase -
G5S35_RS15935 267751..269223 - 1473 WP_183039195.1 benzaldehyde dehydrogenase -
G5S35_RS15940 269477..269665 + 189 WP_065065752.1 CsbD family protein -
G5S35_RS15945 269803..271134 - 1332 WP_065065753.1 type II toxin-antitoxin system HipA family toxin Toxin
G5S35_RS15950 271134..271622 - 489 WP_065065764.1 helix-turn-helix transcriptional regulator Antitoxin
G5S35_RS15955 271758..272699 - 942 WP_065065754.1 phosphatidate cytidylyltransferase -
G5S35_RS15960 272703..273326 - 624 WP_074985787.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
G5S35_RS15965 273313..273957 - 645 WP_183039196.1 CDP-alcohol phosphatidyltransferase family protein -
G5S35_RS15970 274248..275198 - 951 WP_065065756.1 hypothetical protein -
G5S35_RS15975 275335..276192 + 858 WP_074985788.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-68)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 48985.07 Da        Isoelectric Point: 6.3752

>T150600 WP_065065753.1 NZ_CP049135:c271134-269803 [Paraburkholderia tropica]
MARPRQTNRLDLWMNGLPVGHWEIVRGVERLAYAESWLEDEQGRPLSLSLPFTPGNQPLRGEIVTDYFDNLLPDSERIRR
RIATRYRTGGTTPFELLAVLGRDCVGALQLLPAGEAPVDLEHIEGRPLDEHAIAQLLRDTTATPRAAEHDAVDDLRLSIA
GAQEKTALLWHGGEWLLPTGSTPTTHILKLPLGLVGNMRADMRTSVENEWLCARIVAAFGLPIAPCEIAEFEDVKALVVE
RFDRRLSRDGRWIVRLPQEDLCQATGTPGLLKYEADGGPGIDAVMAVLGGSVRAADDRRHFFLAQMIFWLLAATDGHAKN
FSIAHLPGSRYAATPLYDVLSAHPIIGRGRNQLAAQRASLAMAVRGRNAHYRIAQILPRHWIAQGQRVGFTIDQVEEMMA
TVVAQTERVIDEVGAQLPREFPVDVADAVFEGMRRLARVLGTG

Download         Length: 1332 bp

>T150600 NZ_CP064828:c2406359-2406006 [Morganella morganii subsp. morganii]
GTGTGGAAGATAGTCACAACAGATAATTTTACAGCGTGGTTTGCTGAGCAGGATGACGGAGATCGCGCAGCAATACTGGC
AGCGATGCTGGTATTAGAGAAGCGGGGACCCGGCTTACCAAGGCCGTATGCGGATACTGTAAAAGGTTCCCGGTATACGA
ATATGAAAGAGCTTCGTATACAGAGCAGGGGACAACCGATACGGGCATTTTTTGCATTCGACCCTGAGAGAAGAGGCGTC
TTGCTGTGTGCGGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATCCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 163 a.a.        Molecular weight: 17382.24 Da        Isoelectric Point: 11.9821

>AT150600 WP_065065764.1 NZ_CP049135:c271622-271134 [Paraburkholderia tropica]
VDYPLKTVSQLRPLLLGFRKKSGLTQEKLAQRLGISQQSYAAFEANPAAASVERLFRVLRLLSVDMRLLSTEADLAAAPR
AAAAKKSTTPAKTPKAKPKAAAPTQRPSAPANTRGTKKTTAAKTATKTTKAPQAAKAVKTARKQPAPRKTQAALSPRKRE
DW

Download         Length: 489 bp

>AT150600 NZ_CP064828:c2406003-2405701 [Morganella morganii subsp. morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCTGCTGCACGGGTTCAGGCGGATGAGAT
CCTGCTGAATATCCATCTGGCGGAGCTGCGGGAGAAAGTGAAGAAAACACAGGTGGAAATGGCGCAGGCACTGGGAATAA
AACAGCCGACAGTCGCAGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGATGCCATC
GGCGGAAAACTGAATATTGATGTTGAACTGCCGGACGGCACGCATTATATGTTCCGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5X0M3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5WZK2

References