Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3103802..3104321 Replicon chromosome
Accession NZ_CP049134
Organism Paraburkholderia tropica strain IAC135

Toxin (Protein)


Gene name relE Uniprot ID A0A1A5X0A9
Locus tag G5S35_RS14075 Protein ID WP_065065608.1
Coordinates 3104031..3104321 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1H6ZF95
Locus tag G5S35_RS14070 Protein ID WP_074982803.1
Coordinates 3103802..3104044 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S35_RS14055 3099435..3100166 - 732 WP_065065662.1 RNA polymerase sigma factor FliA -
G5S35_RS14060 3100539..3101339 - 801 Protein_2747 MinD/ParA family protein -
G5S35_RS14065 3101332..3103392 - 2061 WP_065065610.1 flagellar biosynthesis protein FlhF -
G5S35_RS14070 3103802..3104044 + 243 WP_074982803.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G5S35_RS14075 3104031..3104321 + 291 WP_065065608.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5S35_RS14080 3104397..3106496 - 2100 WP_065065607.1 flagellar biosynthesis protein FlhA -
G5S35_RS14085 3106493..3107779 - 1287 WP_065065661.1 flagellar type III secretion system protein FlhB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11269.28 Da        Isoelectric Point: 10.7388

>T150599 WP_065065608.1 NZ_CP049134:3104031-3104321 [Paraburkholderia tropica]
MTIYDLKFFKSALKEWQHLDATVREQFRKKLAERLRAPHVESARLAGLPDCYKIKLVASGYRLVYRVIEGELVVLVIAVG
RREAREAYRKAHTRLR

Download         Length: 291 bp

>T150599 NZ_CP064828:1174517-1174840 [Morganella morganii subsp. morganii]
ATGAAAATTCTACCGGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGCCACCCGTTGCAGTCTGGCAATTGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCAGTGATGAAACCGTTATAAAGGAACATTTCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGAATATTGATATCATGAGGGCCCGCCGCGATCTGGGTTTATTAAATCGTAA
TTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8765.13 Da        Isoelectric Point: 4.2220

>AT150599 WP_074982803.1 NZ_CP049134:3103802-3104044 [Paraburkholderia tropica]
MESILARASIGISELKMNPMAAIEKADGPVAILNRNKPVAYLIPASEWEAICDRLEDIELAELVRSRSGDEIVSVKLDDL

Download         Length: 243 bp

>AT150599 NZ_CP064828:1174179-1174496 [Morganella morganii subsp. morganii]
ATGAGCAACATCATTTGGGGCCTGCAGCGCGATATCACGCCGCGCCTGGGAACACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTACCTGGCTGACCGGGCCTGTATCACAGGTAAGTTCAGTGATGCCGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCGGATGGAATCCATGCTGAGCACGGGTGAAATGAATCCTCGCCACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGTGGCTATGTATACGTCGCTGTTTATTCCACTCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5X0A9

Antitoxin

Source ID Structure
AlphaFold DB A0A1H6ZF95

References