Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 827901..828484 Replicon chromosome
Accession NZ_CP049134
Organism Paraburkholderia tropica strain IAC135

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A5XPM9
Locus tag G5S35_RS03655 Protein ID WP_065057353.1
Coordinates 827901..828281 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1A5XNQ3
Locus tag G5S35_RS03660 Protein ID WP_065057354.1
Coordinates 828278..828484 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S35_RS03635 823279..824208 - 930 WP_183038593.1 hypothetical protein -
G5S35_RS03640 824468..825883 - 1416 WP_065057351.1 argininosuccinate lyase -
G5S35_RS03645 826018..826845 - 828 WP_065057352.1 helix-turn-helix transcriptional regulator -
G5S35_RS03650 827100..827864 + 765 WP_183038594.1 class I SAM-dependent methyltransferase -
G5S35_RS03655 827901..828281 - 381 WP_065057353.1 twitching motility protein PilT Toxin
G5S35_RS03660 828278..828484 - 207 WP_065057354.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G5S35_RS03665 828629..831841 - 3213 WP_183038595.1 phosphoenolpyruvate carboxylase -
G5S35_RS03670 832311..833360 + 1050 WP_183038596.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13807.20 Da        Isoelectric Point: 5.6071

>T150598 WP_065057353.1 NZ_CP049134:c828281-827901 [Paraburkholderia tropica]
MSVLVDTSVWVDHFRRRNGALVELMLSDEALAHPMVLAELACGTPPAPRVRTLGDIGLLRSANPVSLQEVMALIEREQLY
GLGCGVVDLILLGSVLITPGARLWTLDRRLAGLAERFDVAWQPPMH

Download         Length: 381 bp

>T150598 NZ_CP064828:932846-933073 [Morganella morganii subsp. morganii]
ATGGCAAGGACGATTGAACGTTCATCTCAGTTTAAAAAAGATTATAAACGGGAAGTTAAGGGTATTTACCGTATGATGTT
AAATGACAGTCTACAGAACATCCTGAATATATTGGTAAATGATCTCCCTATACCTGAAAAATACGCTGATCATCCGCTTA
AAGGAAATTGGCGTACATTTCGTGATTGCCACCTCTATCCTGATTTGATTTTGATTTATAAAAAATAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7440.51 Da        Isoelectric Point: 5.0490

>AT150598 WP_065057354.1 NZ_CP049134:c828484-828278 [Paraburkholderia tropica]
MRTTVTLDDALYEKALEMADPGMEKADLFREAVKTFVRVQAAKRLAALGGSAPEMADIARRRDDTPAS

Download         Length: 207 bp

>AT150598 NZ_CP064828:932590-932862 [Morganella morganii subsp. morganii]
GTGGAATATGTCAGAGCAAAAATTGATCCGAAGCTGAAAGCAGAAGCGATTGAAACGCTTGAATCGATGGGCTTAACAGT
GAGTGACGCGATAAGAATGTTGATGATTCAGATTGTTGAACAGAAAGCGATGCCATTTTGTGTGAAAAGTACACAATATC
GTCATGCTGCACGTATCCGGGCCGCAATAGAAGAGTTGGAGTGCGGGAAAGGCAAAAAATTTGACAGTATTTCAGATTTA
ATGGCGGATCTGCAGGATGGCAAGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5XPM9

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5XNQ3

References