Detailed information of TA system TA150597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 763151..763782
• Replicon: chromosome
• Accession: NZ_CP049134
• Organism: Paraburkholderia tropica strain IAC135

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1A5XPF1
• Locus tag: G5S35_RS03360
• Protein ID: WP_065057309.1
• Coordinates: 763495..763782 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G5S35_RS03355
• Protein ID: WP_183038577.1
• Coordinates: 763151..763498 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5S35_RS03335	758545..759573	+	1029	WP_074984652.1	ABC transporter permease	-
G5S35_RS03340	759678..760658	+	981	WP_074984655.1	substrate-binding domain-containing protein	-
G5S35_RS03345	760736..761785	+	1050	WP_074984657.1	sugar phosphate isomerase/epimerase	-
G5S35_RS03350	761841..762968	+	1128	WP_183038799.1	Gfo/Idh/MocA family oxidoreductase	-
G5S35_RS03355	763151..763498	+	348	WP_183038577.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
G5S35_RS03360	763495..763782	+	288	WP_065057309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G5S35_RS03365	763838..765037	-	1200	WP_080180712.1	ABC transporter substrate-binding protein	-
G5S35_RS03370	765179..766120	-	942	WP_065057310.1	CysB family HTH-type transcriptional regulator	-
G5S35_RS03375	766345..768024	+	1680	WP_183038578.1	nitrite/sulfite reductase	-
G5S35_RS03380	768054..768623	+	570	WP_183038579.1	DUF934 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-56)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10766.40 Da
• Isoelectric Point: 9.9799

>T150597 WP_065057309.1 NZ_CP049134:763495-763782 [Paraburkholderia tropica]
MKLEWSPLALADREAIFDFNETRGAHAAVSVDECIASAVRRLRLYPEIGRRGRVSGTRELVVHGAPFVIAYRVERQTLTV
LRVLHGARRWPAELD

Nucleotide

• Length: 288 bp

>T150597 NZ_CP064828:c887324-887121 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 12320.22 Da
• Isoelectric Point: 10.0058

>AT150597 WP_183038577.1 NZ_CP049134:763151-763498 [Paraburkholderia tropica]
MGASALVQVRIDPALKERATAVLEKMGLTVSDAVRILLTRVANEGALPVGFAVDPATHDAWLRAKVLEALEDARPAVEAD
AVEAHFAKRRAAAARHVDEAEPAAPKLNPVRKRKN

Nucleotide

• Length: 348 bp

>AT150597 NZ_CP064828:c887747-887388 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA

Structures

Toxin

• AlphaFold DB: A0A1A5XPF1