Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1050..1642 Replicon plasmid pEC931_mcr
Accession NZ_CP049122
Organism Escherichia coli strain EC931

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag G6G93_RS24810 Protein ID WP_000520549.1
Coordinates 1050..1298 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag G6G93_RS24815 Protein ID WP_000681613.1
Coordinates 1295..1642 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6G93_RS24800 86..304 + 219 WP_005058042.1 hypothetical protein -
G6G93_RS24805 395..745 + 351 WP_000854259.1 hypothetical protein -
G6G93_RS24810 1050..1298 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
G6G93_RS24815 1295..1642 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G6G93_RS24820 2003..2506 + 504 WP_000781813.1 hypothetical protein -
G6G93_RS24825 2510..3739 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
G6G93_RS24830 3816..4109 + 294 WP_000134733.1 LuxR family transcriptional regulator -
G6G93_RS24835 4106..4321 + 216 WP_000760375.1 EexN family lipoprotein -
G6G93_RS24840 4677..5297 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
G6G93_RS24845 5365..5637 + 273 WP_001328551.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33858 33858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-90)

Antitoxin

Vibrio phage ICP1, Orf50

(21-91)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 12.7138

>T150596 WP_000520549.1 NZ_CP049122:1050-1298 [Escherichia coli]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Download         Length: 249 bp

>T150596 NZ_CP064827:c3790840-3790493 [Morganella morganii subsp. morganii]
ATGGCCTATTATGCATTATCGACAGGTGTTATTACCTGTTCACAGGCGGCGGGGCGCTTCAGACGTAATATGCCTCCGGA
AATTCCGGTTATTCTGCCGGGACGTCTTGCTGTTGATGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAG
ATGCCGCACTGCGGGTCTTGCAGGCAGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCC
AGACGTTTTTATGAGCATACCGGTTTTATACCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCA
GCTGGCAACCGGTATCTATTCTGAATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 14886.21 Da        Isoelectric Point: 12.8607

>AT150596 WP_000681613.1 NZ_CP049122:1295-1642 [Escherichia coli]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 348 bp

>AT150596 NZ_CP064827:c3791145-3790840 [Morganella morganii subsp. morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTTCACGGACATTTGTCGTCTGTCACCATAACCGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References