Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3567..4089 Replicon plasmid pEC931_tetX
Accession NZ_CP049121
Organism Escherichia coli strain EC931

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag G6G93_RS24530 Protein ID WP_000220560.1
Coordinates 3808..4089 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag G6G93_RS24525 Protein ID WP_000121743.1
Coordinates 3567..3818 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6G93_RS24510 499..921 - 423 WP_031942371.1 DNA distortion polypeptide 3 -
G6G93_RS24515 989..1435 - 447 WP_001074386.1 hypothetical protein -
G6G93_RS24520 1475..2311 - 837 WP_001050931.1 replication initiation protein -
G6G93_RS24525 3567..3818 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
G6G93_RS24530 3808..4089 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6G93_RS24535 4235..4558 + 324 WP_001181903.1 hypothetical protein -
G6G93_RS24540 4603..4848 + 246 WP_000356546.1 hypothetical protein -
G6G93_RS24545 4838..5053 + 216 WP_001180116.1 hypothetical protein -
G6G93_RS24550 5146..5475 + 330 WP_000866648.1 hypothetical protein -
G6G93_RS24555 5762..5911 + 150 WP_000003880.1 hypothetical protein -
G6G93_RS24560 5924..6196 + 273 WP_000160399.1 hypothetical protein -
G6G93_RS24565 6523..7068 + 546 WP_038976855.1 hypothetical protein -
G6G93_RS24570 7071..8228 + 1158 WP_000538023.1 hypothetical protein -
G6G93_RS24575 8589..9080 + 492 WP_000872475.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..50626 50626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T150595 WP_000220560.1 NZ_CP049121:3808-4089 [Escherichia coli]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T150595 NZ_CP064827:c1008728-1008525 [Morganella morganii subsp. morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT150595 WP_000121743.1 NZ_CP049121:3567-3818 [Escherichia coli]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT150595 NZ_CP064827:c1009151-1008792 [Morganella morganii subsp. morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTCGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References