Detailed information of TA system TA150594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1981..2540
• Replicon: plasmid pEC931_2
• Accession: NZ_CP049120
• Organism: Escherichia coli strain EC931

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G6G93_RS24025
• Protein ID: WP_187976025.1
• Coordinates: 2265..2540 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y625
• Locus tag: G6G93_RS24020
• Protein ID: WP_001178087.1
• Coordinates: 1981..2265 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6G93_RS24015	46..1077	+	1032	WP_000907852.1	replication initiation protein	-
G6G93_RS24020	1981..2265	+	285	WP_001178087.1	ribbon-helix-helix protein, CopG family	Antitoxin
G6G93_RS24025	2265..2540	+	276	WP_187976025.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6G93_RS24030	2646..2927	+	282	WP_001105066.1	hypothetical protein	-
G6G93_RS24035	3119..3385	-	267	WP_000627832.1	hypothetical protein	-
G6G93_RS24040	3385..3879	-	495	WP_015058884.1	hypothetical protein	-
G6G93_RS24045	3935..4537	-	603	WP_000521606.1	hypothetical protein	-
G6G93_RS24050	4713..5765	-	1053	WP_000655519.1	hypothetical protein	-
G6G93_RS24055	5978..6568	-	591	WP_001401589.1	hypothetical protein	-
G6G93_RS24060	6568..6822	-	255	WP_187976026.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..86557	86557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (9-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-79)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T150594 WP_187976025.1 NZ_CP049120:2265-2540 [Escherichia coli]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T150594 NZ_CP064826:3655643-3655966 [Morganella morganii subsp. morganii]
ATGGATTACCTGGAATTTATCGAAACTAAAATTTTCAGCCATACCCGCAAAGAAATGATGACTGATGATGAATTCCGGGA
ATTTCAGAGCTATCTTTTGGAAAACTACGAACGGGGTAACACGATCAGTCAGACAGGCGGATGTAAGAAGATTCGCTGGC
AACGCAGGGGAACCGGTAAACAAGGCGGCCTCCGGGTCATTTATCACGCCCTTCCCGCTCACGGCAGATTGTACCTGCTT
CTTATCTACCCCAAAAATGTCAAAGATGATCTGAGTAGTCAGGAAAGAACGGTGCTCAGATCGTTATCACAGAAACTGAA
CTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 12194.55 Da
• Isoelectric Point: 12.7731

>AT150594 WP_001178087.1 NZ_CP049120:1981-2265 [Escherichia coli]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Nucleotide

• Length: 285 bp

>AT150594 NZ_CP064826:3656012-3656317 [Morganella morganii subsp. morganii]
ATGGATAAAACACTTTTTGAAAATCTGGTCAGCAGCATGGAAGAGATGGTGGCAATTGAAAAAGGCCACGTTGTTCCGGC
ACAGGAAAACAGGCACAGACACCCGATTCCGGATGTTAAAGCAATCCGCAAGCATGCCGGATTAAAACAGACAGAATTTG
CAGATGCTATCGGTTCCAGTGTTGATCTGGTCCGCAGTTGGGAGCAGCATCGTCGTATTCCGTCAGGGATTGCCTTAAAA
ATGTTGTATCTCATTGAAAAACAACCCGCACTTTTATGTACACTACGATCAATCCCTCTGCGCTGA

Structures

Antitoxin

• AlphaFold DB: U9Y625