Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 18017..18537 Replicon plasmid unnamed1
Accession NZ_CP049116
Organism Pantoea stewartii strain ZJ-FGZX1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A6G6JW05
Locus tag G5574_RS21555 Protein ID WP_039339392.1
Coordinates 18017..18316 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H3RK39
Locus tag G5574_RS21560 Protein ID WP_006121899.1
Coordinates 18319..18537 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5574_RS21540 14743..15747 + 1005 WP_039339386.1 decarboxylating 6-phosphogluconate dehydrogenase -
G5574_RS21545 15765..17135 + 1371 WP_164483281.1 glucose-6-phosphate dehydrogenase -
G5574_RS21550 17153..17848 + 696 WP_054633989.1 ROK family protein -
G5574_RS21555 18017..18316 - 300 WP_039339392.1 CcdB family protein Toxin
G5574_RS21560 18319..18537 - 219 WP_006121899.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G5574_RS21565 19049..19309 + 261 WP_006121900.1 hypothetical protein -
G5574_RS21570 19513..19938 - 426 WP_164483282.1 ATP-binding protein -
G5574_RS21575 19940..20278 - 339 WP_033742520.1 STAS domain-containing protein -
G5574_RS21580 20275..21483 - 1209 WP_006121902.1 SpoIIE family protein phosphatase -
G5574_RS21585 21492..22391 - 900 WP_033742517.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fliC 1..326337 326337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-98)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11004.70 Da        Isoelectric Point: 7.0045

>T150583 WP_039339392.1 NZ_CP049116:c18316-18017 [Pantoea stewartii]
MQFDVYSHKNGKKYPYLVEVQSYLIDTPGRLMVAPLALPGEFVGSGELYPEVLVNGSKYRVVTTDIASVPVKALGDKVGD
VSQYEATIKNAIFRLFWGF

Download         Length: 300 bp

>T150583 NZ_CP064825:c3065548-3065213 [Escherichia coli UTI89]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8516.56 Da        Isoelectric Point: 5.1504

>AT150583 WP_006121899.1 NZ_CP049116:c18537-18319 [Pantoea stewartii]
MKYRTNVTIDKEAYEIFSSAGLNLSKMVNELVTTEARRIRAERWKEENRESMKAFSDFVGEEGSLSDMYRNW

Download         Length: 219 bp

>AT150583 NZ_CP064825:c3065796-3065548 [Escherichia coli UTI89]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6JW05

Antitoxin

Source ID Structure
AlphaFold DB H3RK39

References