Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3937350..3937967 Replicon chromosome
Accession NZ_CP049115
Organism Pantoea stewartii strain ZJ-FGZX1

Toxin (Protein)


Gene name Hha Uniprot ID H3R994
Locus tag G5574_RS18520 Protein ID WP_006117940.1
Coordinates 3937350..3937565 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6G6JU23
Locus tag G5574_RS18525 Protein ID WP_039338473.1
Coordinates 3937590..3937967 (-) Length 126 a.a.

Genomic Context

G5574_RS18490G5574_RS18495G5574_RS18505G5574_RS18535G5574_RS18540G5574_RS18545G5574_RS18500G5574_RS18510G5574_RS18520G5574_RS18525G5574_RS18530G5574_RS18550G5574_RS18555
Location: 3933249..3933587 (339 bp)
Type: Others
Protein ID: WP_003850469.1
Location: 3933621..3934907 (1287 bp)
Type: Others
Protein ID: WP_033738675.1
Location: 3936012..3936569 (558 bp)
Type: Others
Protein ID: WP_006117943.1
Location: 3938817..3939485 (669 bp)
Type: Others
Protein ID: WP_033738793.1
Location: 3939482..3940321 (840 bp)
Type: Others
Protein ID: WP_006117933.1
Location: 3940334..3941212 (879 bp)
Type: Others
Protein ID: WP_033738684.1
Location: 3934956..3935819 (864 bp)
Type: Others
Protein ID: WP_006117944.1
Location: 3936610..3936951 (342 bp)
Type: Others
Protein ID: WP_152998336.1
Location: 3937350..3937565 (216 bp)
Type: Toxin
Protein ID: WP_006117940.1
Location: 3937590..3937967 (378 bp)
Type: Antitoxin
Protein ID: WP_039338473.1
Location: 3938114..3938467 (354 bp)
Type: Others
Protein ID: WP_033738682.1
Location: 3941270..3941410 (141 bp)
Type: Others
Protein ID: WP_006117931.1
Location: 3941422..3941676 (255 bp)
Type: Others
Protein ID: WP_164483024.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G5574_RS184903933249..3933587+339WP_003850469.1P-II family nitrogen regulator-
G5574_RS184953933621..3934907+1287WP_033738675.1ammonium transporter AmtB-
G5574_RS185003934956..3935819-864WP_006117944.1acyl-CoA thioesterase II-
G5574_RS185053936012..3936569+558WP_006117943.1YbaY family lipoprotein-
G5574_RS185103936610..3936951-342WP_152998336.1MGMT family protein-
G5574_RS185203937350..3937565-216WP_006117940.1hemolysin expression modulator HhaToxin
G5574_RS185253937590..3937967-378WP_039338473.1Hha toxicity modulator TomBAntitoxin
G5574_RS185303938114..3938467-354WP_033738682.1hypothetical protein-
G5574_RS185353938817..3939485+669WP_033738793.1ATP-binding cassette domain-containing protein-
G5574_RS185403939482..3940321+840WP_006117933.1metal ABC transporter permease-
G5574_RS185453940334..3941212+879WP_033738684.1metal ABC transporter substrate-binding protein-
G5574_RS185503941270..3941410-141WP_006117931.1type B 50S ribosomal protein L36-
G5574_RS185553941422..3941676-255WP_164483024.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8528.91 Da        Isoelectric Point: 9.4825

>T150582 WP_006117940.1 NZ_CP049115:c3937565-3937350 [Pantoea stewartii]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T150582 NZ_CP064825:c2228120-2227869 [Escherichia coli UTI89]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14622.23 Da        Isoelectric Point: 4.4699

>AT150582 WP_039338473.1 NZ_CP049115:c3937967-3937590 [Pantoea stewartii]
MDEYSPKRHDIAQLKYVCESLFDASMATLTDSHHGWVNDPTADGNLQLNDLIEHIASFTMNYKIKHAEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNLFQEECAYLQQPSHSL

Download         Length: 378 bp

>AT150582 NZ_CP064825:c2227872-2227618 [Escherichia coli UTI89]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH3R994

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6G6JU23

References