Detailed information of TA system TA150577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3925944..3926758
• Replicon: chromosome
• Accession: NZ_CP049112
• Organism: Escherichia coli strain WF5-5-T2

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: G6R06_RS19210
• Protein ID: WP_001054376.1
• Coordinates: 3925944..3926201 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: G6R06_RS19215
• Protein ID: WP_103119170.1
• Coordinates: 3926213..3926758 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6R06_RS19185 (3921232)	3921232..3922338	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
G6R06_RS19190 (3922403)	3922403..3923383	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
G6R06_RS19195 (3923493)	3923493..3923698	+	206	Protein_3748	HNH endonuclease	-
G6R06_RS19200 (3923966)	3923966..3925206	-	1241	Protein_3749	helicase YjhR	-
G6R06_RS19205 (3925322)	3925322..3925453	+	132	WP_001309182.1	hypothetical protein	-
G6R06_RS19210 (3925944)	3925944..3926201	+	258	WP_001054376.1	YjhX family toxin	Toxin
G6R06_RS19215 (3926213)	3926213..3926758	+	546	WP_103119170.1	N-acetyltransferase	Antitoxin
G6R06_RS19220 (3926814)	3926814..3927560	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
G6R06_RS19225 (3927729)	3927729..3927947	+	219	Protein_3754	hypothetical protein	-
G6R06_RS19230 (3927985)	3927985..3928101	+	117	Protein_3755	VOC family protein	-
G6R06_RS19235 (3928346)	3928346..3929467	+	1122	WP_000010829.1	M42 family metallopeptidase	-
G6R06_RS19240 (3929464)	3929464..3929742	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
G6R06_RS19245 (3929754)	3929754..3931067	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T150577 WP_001054376.1 NZ_CP049112:3925944-3926201 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T150577 NZ_CP064825:c1619554-1619276 [Escherichia coli UTI89]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19930.86 Da
• Isoelectric Point: 6.4176

>AT150577 WP_103119170.1 NZ_CP049112:3926213-3926758 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT150577 NZ_CP064825:c1619276-1618992 [Escherichia coli UTI89]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Structures

Toxin

• AlphaFold DB: S1PA82