Detailed information of TA system TA150544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3924820..3925634
• Replicon: chromosome
• Accession: NZ_CP049110
• Organism: Escherichia coli strain WF5-5-T1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: G5631_RS19200
• Protein ID: WP_001054376.1
• Coordinates: 3924820..3925077 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: G5631_RS19205
• Protein ID: WP_103119170.1
• Coordinates: 3925089..3925634 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5631_RS19175 (3920108)	3920108..3921214	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
G5631_RS19180 (3921279)	3921279..3922259	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
G5631_RS19185 (3922369)	3922369..3922574	+	206	Protein_3746	HNH endonuclease	-
G5631_RS19190 (3922842)	3922842..3924082	-	1241	Protein_3747	helicase YjhR	-
G5631_RS19195 (3924198)	3924198..3924329	+	132	WP_001309182.1	hypothetical protein	-
G5631_RS19200 (3924820)	3924820..3925077	+	258	WP_001054376.1	YjhX family toxin	Toxin
G5631_RS19205 (3925089)	3925089..3925634	+	546	WP_103119170.1	N-acetyltransferase	Antitoxin
G5631_RS19210 (3925690)	3925690..3926436	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
G5631_RS19215 (3926605)	3926605..3926823	+	219	Protein_3752	hypothetical protein	-
G5631_RS19220 (3926861)	3926861..3926977	+	117	Protein_3753	VOC family protein	-
G5631_RS19225 (3927222)	3927222..3928343	+	1122	WP_000010829.1	M42 family metallopeptidase	-
G5631_RS19230 (3928340)	3928340..3928618	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
G5631_RS19235 (3928630)	3928630..3929943	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fimE / fimB	3915464..3970311	54847

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T150544 WP_001054376.1 NZ_CP049110:3924820-3925077 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T150544 NZ_CP064781:c224410-223913 [Azospira restricta]
GTGAGCCTGCGCGGGCCGGAGCCCCTGGGGGCTCAGCACAGACTAGAAAGCTTCGACTGCGGCCAGCCTACCCTGAACGA
CTGGTTGTTGCGCCATGCCCGCCAAGCCCAAGCCAGTGGCTCGGCCAAGACATTTGTAGTTGCCGACGATGATCGCGTGG
CCGGCTACTTCAGCCTGACCGTTGGCCAGATCGATATGCTGGAAGTTCCTGAGCGCATCAGCAAGGGGATGGGGCAGTAC
CCGGTGCCAGTGGTCATCCTGGCTCGCCTGGCGGTGTCCACTCCTGATCAGGGGCGCGGCGTTGGCTTTGGCATGCTTCA
GGATGCGATCCGCCGCACGCTTCTCATCGCTGAGCAGGCCGGCATACGGGCAATGCTGACCCACCCCATCAACGAGGAAG
CGTCGAGCTTCTACACCCGTTTCGGGTTCATCGCTTCGCCACTGCGCGAACGGCAATTGCTGCTGCTTCTCAAAGACGCA
AGACGCTGGGTGGCATAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19930.86 Da
• Isoelectric Point: 6.4176

>AT150544 WP_103119170.1 NZ_CP049110:3925089-3925634 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT150544 NZ_CP064781:c224700-224407 [Azospira restricta]
ATGGCTGCCATTGCGTCTTCACCCGCTGCCCGGTCCGCGCGTTTGGGGCTACGCGCCACACCCGAACAGGAAGCCGTGCT
GCGCCGTGCTGCCGAAGTAGCGCACAAATCCCTGACCGAATTCATCCTGGACAGTGCTTGCCTGGCCGCCGAGCGGACCT
TGCTGGATCAGCGTCTGTTCATGGTTTCCGGCAGCCAATATCAGACGCTGATGGAGTTGCTGGAGCGCCCTGAGCAGACC
AACGAGGGCTTACGTGATCTTTTCTCCCGCAAAGCACCCTGGGATGCCAAGTGA

Structures

Toxin

• AlphaFold DB: S1PA82