150538

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3372375..3372993 Replicon chromosome
Accession NZ_CP049110
Organism Escherichia coli strain WF5-5-T1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G5631_RS16470 Protein ID WP_001291435.1
Coordinates 3372775..3372993 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G5631_RS16465 Protein ID WP_000344800.1
Coordinates 3372375..3372749 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5631_RS16455 (3367464) 3367464..3368657 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G5631_RS16460 (3368680) 3368680..3371829 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
G5631_RS16465 (3372375) 3372375..3372749 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G5631_RS16470 (3372775) 3372775..3372993 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G5631_RS16475 (3373165) 3373165..3373716 + 552 WP_000102564.1 maltose O-acetyltransferase -
G5631_RS16480 (3373832) 3373832..3374302 + 471 WP_000136192.1 YlaC family protein -
G5631_RS16485 (3374466) 3374466..3376016 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G5631_RS16490 (3376058) 3376058..3376411 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G5631_RS16500 (3376790) 3376790..3377101 + 312 WP_000409911.1 MGMT family protein -
G5631_RS16505 (3377132) 3377132..3377704 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150538 WP_001291435.1 NZ_CP049110:3372775-3372993 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150538 NZ_CP064780:449541-449693 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT150538 WP_000344800.1 NZ_CP049110:3372375-3372749 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150538 NZ_CP064780:449757-449891 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References