Detailed information of TA system TA150514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 1304426..1304964
• Replicon: chromosome
• Accession: NZ_CP049109
• Organism: Sphingosinithalassobacter sp. zrk23

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G5C33_RS06435
• Protein ID: WP_165326457.1
• Coordinates: 1304665..1304964 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: G5C33_RS06430
• Protein ID: WP_165326456.1
• Coordinates: 1304426..1304668 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5C33_RS06395	1300123..1300653	-	531	WP_165326449.1	DNA methylase	-
G5C33_RS06400	1300650..1300865	-	216	WP_165326450.1	hypothetical protein	-
G5C33_RS06405	1301298..1301717	+	420	WP_165326451.1	MucR family transcriptional regulator	-
G5C33_RS06410	1301867..1302451	-	585	WP_165326452.1	tyrosine-type recombinase/integrase	-
G5C33_RS06415	1302668..1302901	+	234	WP_165326453.1	hypothetical protein	-
G5C33_RS06420	1302943..1303317	+	375	WP_165326454.1	hypothetical protein	-
G5C33_RS06425	1303322..1304287	-	966	WP_165326455.1	hypothetical protein	-
G5C33_RS06430	1304426..1304668	+	243	WP_165326456.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G5C33_RS06435	1304665..1304964	+	300	WP_165326457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G5C33_RS06440	1305052..1305354	+	303	WP_165326458.1	hypothetical protein	-
G5C33_RS06445	1305671..1306660	+	990	WP_165326459.1	TauD/TfdA family dioxygenase	-
G5C33_RS06450	1306715..1306975	+	261	WP_165326460.1	hypothetical protein	-
G5C33_RS06455	1307035..1308345	-	1311	WP_165326461.1	relaxase	-
G5C33_RS06460	1308447..1308821	-	375	WP_165326462.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	gmd	1277701..1428499	150798

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11263.72 Da
• Isoelectric Point: 5.5803

>T150514 WP_165326457.1 NZ_CP049109:1304665-1304964 [Sphingosinithalassobacter sp. zrk23]
MSGYRLSKAAADDLARIAEYTVETFGPAQALAYRDSLISTFEFLAENPRAARLRNELTPPVRMHPHKPHLIIYSVEDDAI
LIVRIRHGREDWISEASDE

Nucleotide

• Length: 300 bp

>T150514 NZ_CP064761:c2510763-2510581 [Companilactobacillus futsaii]
ATGCCAATGACACAAAAGGAAATGGTAAAACTATTGAAAACTAATGGATGGGCAAAAACAATTGGAGGAAAAGGCTCCCA
TATTAAAATGTCCAAGTTAGGAAAGCGTCCCATCACAGTGCCACATGGAGAACTTAATAAGTTCACAGAACGTGCAATAA
AAAAGGAAGCTGGATTAAAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8952.05 Da
• Isoelectric Point: 4.7962

>AT150514 WP_165326456.1 NZ_CP049109:1304426-1304668 [Sphingosinithalassobacter sp. zrk23]
MATMNVSLPEAMKDWVDGQMQAGRYSSASDYVRDLIRKDQERNSKIAAMQKLIDEGFASGVSERTVEAIFEDAIKRHAGE

Nucleotide

• Length: 243 bp

>AT150514 NZ_CP064761:c2510551-2510096 [Companilactobacillus futsaii]
ATGTTAGTAAGTTATCCCGCTCTATTTTATTATGATCAATCTGAAAAGGTACCGTTCTTTATTACTTTTCCTGACTTTAC
TAATTCTGGGACTCAAGGAAATGACGTAACAGATGCAATGTCGATGGCAACAGATTGGTTAGGAATCAATGTTGCTGATT
ATCTTGAAAATAATCGTCCTTTACCAGCCCCTTCAACATTGGAGGAAATTTCGTTAGCAAAAAATAATCCATATCCTGAA
GATTTAAAGTATGATTCAAAGCGTTCTTTTAAATCGATGGTTCTAGTTGATTTAGATAGCTATTTAAAAGGTGATATTAA
AATTAAAAAGACAGTTTCTATACCAAAGTGGGCCGATCGGGCTGGTGCAGATTTGCATATTAATTATTCGGCGACACTCA
CTGAAGCGATAGCTCAAGCTAAAATGTTGCATGATTCTAAAATTATGAATAAATAA