Detailed information of TA system TA150512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1393532..1394102
• Replicon: chromosome
• Accession: NZ_CP049107
• Organism: Sphingomonas sp. MK52

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G6P88_RS06365
• Protein ID: WP_165322397.1
• Coordinates: 1393818..1394102 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G6P88_RS06360
• Protein ID: WP_165322396.1
• Coordinates: 1393532..1393837 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6P88_RS06350	1389526..1391982	-	2457	WP_165322395.1	TonB-dependent receptor	-
G6P88_RS06355	1392149..1393468	+	1320	WP_165324953.1	MFS transporter	-
G6P88_RS06360	1393532..1393837	+	306	WP_165322396.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
G6P88_RS06365	1393818..1394102	+	285	WP_165322397.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6P88_RS06370	1394152..1395558	-	1407	WP_165322398.1	MATE family efflux transporter	-
G6P88_RS06375	1395560..1398262	-	2703	WP_165322399.1	valine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-52)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10613.20 Da
• Isoelectric Point: 5.0745

>T150512 WP_165322397.1 NZ_CP049107:1393818-1394102 [Sphingomonas sp. MK52]
VAKTRLEWHAAARADLLAIVDYISDDNIDAALALLDDVEAKPAQLADNPKLYQAGRLPGTREMLVRRSYIVVYTEDEQVV
TILRILHAAQMWPR

Nucleotide

• Length: 285 bp

>T150512 NZ_CP064761:1325684-1325947 [Companilactobacillus futsaii]
ATGTCTTATTCAATAAAATTTAAAAATTCTTCTAAAAATGATTTAAAAAAGATAAAGAATAGTCCATTTTGTAAGAAATT
TGACGAAATAATTAAAAAGTTGTCAGTAAATCCATATGATCCATCAGATAACTTTGAAAAATTGTTTCCACCAGAAGATA
AACTTTATTCTAGAAGATTGAATATTCAACATCGTATTGTATATTCAATTGATGAGGAGAAACAAATAGTACATATTTAT
TCAGCGTGGAATCATTACGCGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10973.46 Da
• Isoelectric Point: 7.3216

>AT150512 WP_165322396.1 NZ_CP049107:1393532-1393837 [Sphingomonas sp. MK52]
MTARSSMLHVRVDEALKVEASEKLANVGLTLSDAVRILLTRIAKEGGLPPGLTSDPASHDAWFRAKVREALNDPRSTISH
DEVMDDARALIAGKRRGQNEA

Nucleotide

• Length: 306 bp

>AT150512 NZ_CP064761:1325418-1325681 [Companilactobacillus futsaii]
ATGCAAAGAATGACTAATCCTACTCAAGCAAGAAAAGACTTTTATAAAATTATTAAATCAGTTAATGAAAATTCTACTCC
TATAGAGATAAATGGACGAACAGAAGATGACAGTGCAGTTATTATGAGTGCTAAAGATTATAGATCATTACAGGAAACAC
TCTACTTAATGAATGACGGTACGCTTAATAAAGTTCATAAAGCTATTGCTGACGATTCTGGTGAGACTGATATAACAAAT
GGCGTTGATTGGGATAAAATTTAG