Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1859485..1859953 Replicon chromosome
Accession NZ_CP049091
Organism Staphylococcus haemolyticus strain SE3.9

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag RES7_RS09070 Protein ID WP_011276326.1
Coordinates 1859765..1859953 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A318R523
Locus tag RES7_RS09065 Protein ID WP_016931010.1
Coordinates 1859485..1859742 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RES7_RS09030 (RES7_009015) 1854648..1855373 - 726 WP_085059890.1 type I 3-dehydroquinate dehydratase -
RES7_RS09035 (RES7_009020) 1855536..1855958 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
RES7_RS09040 (RES7_009025) 1856235..1856726 + 492 WP_016931014.1 GNAT family N-acetyltransferase -
RES7_RS09045 (RES7_009030) 1856857..1857474 + 618 WP_161511439.1 LysE family transporter -
RES7_RS09050 (RES7_009035) 1857662..1858270 - 609 WP_161511657.1 histidine phosphatase family protein -
RES7_RS09055 (RES7_009040) 1858497..1858739 + 243 WP_011276324.1 hypothetical protein -
RES7_RS09060 (RES7_009045) 1858731..1858934 - 204 WP_016931011.1 sterile alpha motif-like domain-containing protein -
RES7_RS09065 (RES7_009050) 1859485..1859742 + 258 WP_016931010.1 hypothetical protein Antitoxin
RES7_RS09070 (RES7_009055) 1859765..1859953 + 189 WP_011276326.1 hypothetical protein Toxin
RES7_RS09075 (RES7_009060) 1860071..1860652 + 582 WP_016931009.1 lipoprotein N-acylation protein LnsA -
RES7_RS09080 (RES7_009065) 1860700..1860936 - 237 WP_016931008.1 hypothetical protein -
RES7_RS09085 (RES7_009070) 1861106..1861852 + 747 WP_053024266.1 membrane lipoprotein lipid attachment site-containing protein -
RES7_RS09090 (RES7_009075) 1861922..1862530 - 609 WP_053024265.1 GNAT family N-acetyltransferase -
RES7_RS09095 (RES7_009080) 1862667..1863413 + 747 WP_016931005.1 poly-gamma-glutamate hydrolase family protein -
RES7_RS09100 (RES7_009085) 1863489..1863776 + 288 WP_016931004.1 hypothetical protein -
RES7_RS09105 (RES7_009090) 1864016..1864240 + 225 WP_016931003.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-83)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T150475 WP_011276326.1 NZ_CP049091:1859765-1859953 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T150475 NZ_CP064689:8235210-8235551 [Bradyrhizobium sp. 200]
TTGAGATATAAGCAGGCGTGCCCTTGGCGAGTTGAAATCCTCGACGAAACCGTCGCCGCAGAGATCGCTGCCCTTCCGGC
CGACATGCAGGCGCGGTTTTTGCGACTTGCCGAGCGGATCACGTCAGCAGGGCTGGAAAGCCTGAGCGAACCGCATGTGA
AGCACATCGGGGGGAAGCTCTGGGAGTTGCGCTTGACAGGGCGCGATGGAATTGCCCGCGCGCTTTACGTCACGGCGATC
GGCAGAAGGGTCGTCGTGGTTCGCGCCTTCGTGAAGAAGACGCAGAAGACGCCGCGCGCCGAGATCGAACTCGCGCAGCG
GCGAGCAAAGGAGATCACATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9864.88 Da        Isoelectric Point: 4.1050

>AT150475 WP_016931010.1 NZ_CP049091:1859485-1859742 [Staphylococcus haemolyticus]
MNNNKIFWINIFITLLFLGFNIIVTYNAELDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIAMLLYYIYPI
VYTFF

Download         Length: 258 bp

>AT150475 NZ_CP064689:8235548-8235829 [Bradyrhizobium sp. 200]
ATGACCATTCAGTTTGATAAGCTCAAGGCCCGCCTGCTCGCCAACCCCAAGGTCAAGGCCGAGTATGATGCGCTCGCGCC
GGAGTTCGAGATTGCCGCTGAGTTGCTCCGCGCTCGCTTGCGCGCGGGCTTGTCGCAGGCCGAGCTTGCAGCCCGGATGG
GCACCAGCCAATCCACCATCGCGCGGCTTGAAAACGGCCAAACGCTTCCGAGCACCAAGACGCTGCTGCGCTACGCCGAG
GCAACCGGCAGCCGGGTACGCGTGCGGCTCTCGGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A318R523

References