Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820373..820905 Replicon chromosome
Accession NZ_CP049091
Organism Staphylococcus haemolyticus strain SE3.9

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag RES7_RS03955 Protein ID WP_011275272.1
Coordinates 820540..820905 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K0A6Q6
Locus tag RES7_RS03950 Protein ID WP_037538759.1
Coordinates 820373..820543 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RES7_RS03925 (RES7_003925) 816159..816638 + 480 WP_161511379.1 PH domain-containing protein -
RES7_RS03930 (RES7_003930) 816631..818154 + 1524 WP_161511380.1 PH domain-containing protein -
RES7_RS03935 (RES7_003935) 818147..818674 + 528 WP_037551985.1 PH domain-containing protein -
RES7_RS03940 (RES7_003940) 818684..819043 + 360 WP_037551987.1 holo-ACP synthase -
RES7_RS03945 (RES7_003945) 819139..820287 + 1149 WP_161511381.1 alanine racemase -
RES7_RS03950 (RES7_003950) 820373..820543 + 171 WP_037538759.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
RES7_RS03955 (RES7_003955) 820540..820905 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RES7_RS03960 (RES7_003960) 821212..822213 + 1002 WP_085060547.1 PP2C family protein-serine/threonine phosphatase -
RES7_RS03965 (RES7_003965) 822312..822638 + 327 WP_011275274.1 anti-sigma factor antagonist -
RES7_RS03970 (RES7_003970) 822667..823119 + 453 WP_052071620.1 anti-sigma B factor RsbW -
RES7_RS03975 (RES7_003975) 823094..823864 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T150473 WP_011275272.1 NZ_CP049091:820540-820905 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T150473 NZ_CP064689:4118638-4119030 [Bradyrhizobium sp. 200]
ATGATCGTCGTCGACGCCTCGGCCTTGCTCGAAGCGCTCCTCCGCACACCGGCGGCACGGGCGGTGGAAGAACGGCTATT
CGAACCTCAACAGACGCTGCATGCGCCTCATCTGCTCGATATCGAAGTCGCGCAGGTCATCCGCCGGTATGCTGCAAAGG
GCGAGATCGACGACGAACGCGGCCGCGCGGCTCTTGCCGACCTCGCTGACTTTCCCTTCCGCCGATACCCGCATGATTTC
CTTTTGCCGCGTGTCTGGGATTTGCGGAACAATCTCACGGCCTATGATGCCGTCTACGTCGCCCTTGCCGAAGCGCTCGA
CGCTGCGTTGCTTACGCGCGATCAACGTCTCGCCGCTGCGGCAGGTCATCATGCGAGAGTCGAACTGGTATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT150473 WP_037538759.1 NZ_CP049091:820373-820543 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYIISNYKSE

Download         Length: 171 bp

>AT150473 NZ_CP064689:4118411-4118641 [Bradyrhizobium sp. 200]
ATGACCACGATGATCCAAATTCGTAATGTTCCGGATGCGCTGCACCGTCGGCTCAAATCGCGCGCGGCGCTGGCGGGCAT
GTCGCTCTCCGATTACCTGCTCAGTGAGATTCGTCAGGTCGCCGAGCGGCCGACACTCGATGAATTGCGTGCGCGTTTGG
AGCGCCGCCCCGGAATGACGCCCTCCGTGTCGCCAGTTCAGGCAATCCGCGCTGAACGTGATCGCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2K0A6Q6

References