Detailed information of TA system TA150472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 809357..809868
• Replicon: chromosome
• Accession: NZ_CP049091
• Organism: Staphylococcus haemolyticus strain SE3.9

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: A0A2K0A6P2
• Locus tag: RES7_RS03895
• Protein ID: WP_037551971.1
• Coordinates: 809662..809868 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: RES7_RS03890
• Protein ID: WP_037538785.1
• Coordinates: 809357..809650 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RES7_RS03865 (RES7_003865)	804484..805275	+	792	WP_161511383.1	hydroxyethylthiazole kinase	-
RES7_RS03870 (RES7_003870)	805277..805915	+	639	WP_085060557.1	thiamine phosphate synthase	-
RES7_RS03875 (RES7_003875)	806004..806879	+	876	WP_161511375.1	membrane protein insertase YidC	-
RES7_RS03880 (RES7_003880)	806944..807585	-	642	WP_085060556.1	HD domain-containing protein	-
RES7_RS03885 (RES7_003885)	807685..809169	-	1485	WP_161511376.1	cardiolipin synthase	-
RES7_RS03890 (RES7_003890)	809357..809650	+	294	WP_037538785.1	copper-sensing transcriptional repressor CsoR	Antitoxin
RES7_RS03895 (RES7_003895)	809662..809868	+	207	WP_037551971.1	heavy-metal-associated domain-containing protein	Toxin
RES7_RS03900 (RES7_003900)	809976..810113	+	138	WP_011275260.1	Lmo0850 family protein	-
RES7_RS03905 (RES7_003905)	810162..811352	-	1191	WP_037551974.1	FtsW/RodA/SpoVE family cell cycle protein	-
RES7_RS03910 (RES7_003910)	811770..812840	+	1071	WP_053025522.1	D-alanine--D-alanine ligase	-
RES7_RS03915 (RES7_003915)	812856..814211	+	1356	WP_161511377.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (15-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7841.79 Da
• Isoelectric Point: 4.0742

>T150472 WP_037551971.1 NZ_CP049091:809662-809868 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISFETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T150472 NZ_CP064689:c3710852-3710448 [Bradyrhizobium sp. 200]
ATGCCCGGTAGTTTCTTCGACACCAACGTCCTCGTCTACCTCGCATCAGGCGATGTGACGAAGGCCGATCGGGCGGAAGC
TACTCTTGCCAAGGGTGGTTCAATCAGCGTGCAAGTTCTGAACGAACTTGCCAACGTCGCGCGCAGGAAAATGCAGATGT
CCTGGGACGAGACGCATGCATTCCTCAACATGTTGCGAGGCCTGCTGACGGTTCATCCCCTCACCGTCGAGACCCACGAA
ACGGGACTTCGACTGGCGGAGCGATACGGCCTTTCAATCTATGACTCGATGATTGCCGCCTCGGCACTTGACGCCGGTTG
CGACACGCTCTGGTCGGAGGATATGCAGCACGGCATGAAGCTCGACGAGGGATTACGCATCGCCAATCCGTTTCGTGGTG
GATAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11236.86 Da
• Isoelectric Point: 6.6364

>AT150472 WP_037538785.1 NZ_CP049091:809357-809650 [Staphylococcus haemolyticus]
MNNHENAHHSEQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT150472 NZ_CP064689:c3711072-3710842 [Bradyrhizobium sp. 200]
ATGCAGGTCGCAAAATGGGGGAACAGCCTTGCCGTTCGCCTTCCAGCCGTCGTGGTCGAAGCGCTCGGCCTCAAGGAAGG
CGACGAGATCGAAATCCACGTCGCGGAGAGACGACAGTTCAGCATAGCGCGCAAGCCCGGACGCGACGAGTGGTTGAAGC
GCCTTCGCACCTTCCGCGGTCGCCTCCCTGCCGACTTCAAGTTCGACCGGGACGAGGCGAATGCCCGGTAG

Structures

Toxin

• AlphaFold DB: A0A2K0A6P2