Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1730392..1731028 Replicon chromosome
Accession NZ_CP049090
Organism Glaesserella parasuis strain aHPS7

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYT4
Locus tag G5S31_RS08425 Protein ID WP_021113607.1
Coordinates 1730852..1731028 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143CEF9
Locus tag G5S31_RS08420 Protein ID WP_021113608.1
Coordinates 1730392..1730805 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S31_RS11550 1725639..1725812 + 174 WP_202116931.1 hypothetical protein -
G5S31_RS08410 1725995..1729648 + 3654 WP_164689569.1 tape measure protein -
G5S31_RS08415 1729658..1730395 + 738 WP_160421846.1 phage minor tail protein L -
G5S31_RS08420 1730392..1730805 - 414 WP_021113608.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G5S31_RS08425 1730852..1731028 - 177 WP_021113607.1 type II toxin-antitoxin system HicA family toxin Toxin
G5S31_RS08430 1731114..1731875 + 762 WP_160405333.1 C40 family peptidase -
G5S31_RS08435 1731905..1732417 + 513 WP_164689572.1 tail assembly protein -
G5S31_RS08440 1732471..1732995 + 525 WP_021112309.1 hypothetical protein -
G5S31_RS08445 1732923..1733210 + 288 Protein_1640 excinuclease ABC subunit UvrA -
G5S31_RS08450 1733294..1733674 + 381 WP_010786782.1 YacL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1687238..1738476 51238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-63)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6704.84 Da        Isoelectric Point: 10.8513

>T150471 WP_021113607.1 NZ_CP049090:c1731028-1730852 [Glaesserella parasuis]
MKQSEFLRWLIAQGVVKEEGSKHIKLYYNGNQSTMPRQPSKEIKNGTMRAIKKQLGLN

Download         Length: 177 bp

>T150471 NZ_CP064689:c1621229-1620963 [Bradyrhizobium sp. 200]
ATGAAAACCGCTTGGACGGAAGATGCTTGGCAAGAGTATCTTCAATGGCAAAAAGAGGATGAAAAGATCCTCGAAGTCAT
AAACGGTCTAATCAAAGATATTAAGCGCGATCCGTTCAAGGGGCTTGGGAAACCAGAGCCCCTTAAACATGCGCTCCAGG
GATGGTGGTCGCGCCGCATTTCAGGCGAACATCGCTTGGTGTATCGCGTTTCTGGAAAGGGTGACACTCAGCAACTCGAC
ATTGCTCAGTGCCGATATCATTACTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15572.78 Da        Isoelectric Point: 4.3878

>AT150471 WP_021113608.1 NZ_CP049090:c1730805-1730392 [Glaesserella parasuis]
MLYPARFEFEDGSYNVSFRDIPEALTCGDNYEDALEMAKDALLTSMDFYFEDHRKVPLPSPPQEGEVLIELPTSIFAKVL
LLNEMVDQNISNVELAKRIAVKPQEVQRITNLGHSTKIDTIARAINALDKQFELRVV

Download         Length: 414 bp

>AT150471 NZ_CP064689:c1621504-1621226 [Bradyrhizobium sp. 200]
ATGGCGCACGTTTCTTACACCGAACTGCGTAACAACCTCGCATCCTACATGGATGAGGTCTGCGATGATCGCGCGCCCCT
GTTCGTGACCCGCCAGAATGCCCGCACCGTCGTTCTCCTGGCCGAGGATGAGTATGAGAGTCTTATGGCGACTGTCCACC
TCCTGAAGAGTCCCGCCAATGCAGTACGTCTTCTACGTTCCATCAAGGAAGCGGACGAGGGCAGACTAACTGAACGCGAG
TTGATCGAGCCAACAAAGGCAGGTTCGGCCAAGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYT4

Antitoxin

Source ID Structure
AlphaFold DB A0A143CEF9

References