Detailed information of TA system TA150470

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1716209..1716822
• Replicon: chromosome
• Accession: NZ_CP049090
• Organism: Glaesserella parasuis strain aHPS7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: G5S31_RS08325
• Protein ID: WP_200859958.1
• Coordinates: 1716655..1716822 (-)
• Length: 56 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: U4SMI8
• Locus tag: G5S31_RS08320
• Protein ID: WP_021110735.1
• Coordinates: 1716209..1716616 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5S31_RS08280	1712033..1712686	-	654	WP_005714960.1	LexA family transcriptional regulator	-
G5S31_RS08285	1712822..1713028	+	207	WP_012621794.1	helix-turn-helix transcriptional regulator	-
G5S31_RS08290	1713049..1713294	+	246	WP_160405314.1	hypothetical protein	-
G5S31_RS08295	1713385..1714038	+	654	WP_021118456.1	phage regulatory protein/antirepressor Ant	-
G5S31_RS08300	1714035..1714820	+	786	WP_075593099.1	replication protein	-
G5S31_RS08305	1714820..1715491	+	672	WP_160405312.1	holin	-
G5S31_RS08310	1715514..1715711	+	198	WP_071610285.1	hypothetical protein	-
G5S31_RS08315	1715747..1716175	+	429	WP_164689675.1	recombination protein NinB	-
G5S31_RS08320	1716209..1716616	-	408	WP_021110735.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G5S31_RS08325	1716655..1716822	-	168	WP_200859958.1	type II toxin-antitoxin system HicA family toxin	Toxin
G5S31_RS08330	1716928..1717218	+	291	WP_021110734.1	DUF1364 domain-containing protein	-
G5S31_RS08335	1717215..1717619	+	405	WP_160405310.1	RusA family crossover junction endodeoxyribonuclease	-
G5S31_RS08340	1717616..1717993	+	378	WP_160405308.1	antitermination protein	-
G5S31_RS08345	1718002..1718220	-	219	WP_012621837.1	hypothetical protein	-
G5S31_RS08350	1718517..1718693	+	177	WP_005714781.1	hypothetical protein	-
G5S31_RS08355	1718885..1719064	+	180	WP_021109607.1	hypothetical protein	-
G5S31_RS08360	1719057..1719521	-	465	WP_005714705.1	hypothetical protein	-
G5S31_RS08365	1719625..1719900	+	276	WP_202116933.1	hypothetical protein	-
G5S31_RS08370	1719875..1720420	+	546	WP_160405306.1	lysozyme	-
G5S31_RS08375	1720393..1720737	+	345	WP_160421850.1	DUF2570 family protein	-
G5S31_RS08380	1720700..1720915	+	216	WP_202116934.1	hypothetical protein	-
G5S31_RS08385	1721140..1721286	+	147	WP_164681526.1	hypothetical protein	-
G5S31_RS08390	1721302..1721817	+	516	WP_160421849.1	terminase small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1687238..1738476	51238

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-55)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 56 a.a.
• Molecular weight: 6272.42 Da
• Isoelectric Point: 11.0319

>T150470 WP_200859958.1 NZ_CP049090:c1716822-1716655 [Glaesserella parasuis]
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL

Nucleotide

• Length: 168 bp

>T150470 NZ_CP064688:5799134-5799559 [Bradyrhizobium sp. 40]
GTGAATCTACTGCTCGACACCAACGTGTTGTCGGAGGTCCAGAGGCCGGCCCCTTCGCCGAAAGTCCTGTCATGGCTTGA
TACGATCGACGAGGATCGTGCGTTCATCAGCGTGGCATCGATCGCCGAGCTTCGCCGCGGCATCGCATTGCTGGAGGACG
GCCGTCGGCGCGCAGCACTGGCCGCCTGGCTTGCCCACGATCTGCCGGAGCGTTTTGCCGGGCGTACCCTGTCGATCGAC
CACGCGGTGGCCGAACGCTGGGGTGACCTGATGGCTCAGAGCCGCAGAAGCGGCGTCGCATTGTCTGTCATGGACGGCTT
CTTTGCCGCGACCGCTCTCGCGAACAACCTCATGCTCGTCACGCACAATGTGACGGATTTCGCGGTGTTCGGCGTCCCGC
TGCTGAACCCGTGGGACGACCCATAG

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14904.94 Da
• Isoelectric Point: 4.6143

>AT150470 WP_021110735.1 NZ_CP049090:c1716616-1716209 [Glaesserella parasuis]
MLYPLIFEQVSDGYVVAIPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Nucleotide

• Length: 408 bp

>AT150470 NZ_CP064688:5798868-5799137 [Bradyrhizobium sp. 40]
ATGACAGGCCACAGCACTGCACCAGACTCACCAGCGACTGACTCGTGGACGCTTGCCAACGCCAAGGCCCGGCTATCCGA
GGTGATCGACCGTGCTCAAGCCGGCCCGCAAATCATCACTCGACACGGCAAGCCCAATGCGGTGATCGTTTCCGCCGAGG
AATGGGCGCGCAAGACGGCGCGCAAAGGTACCTTGGCCGAATTCCTGCTGGCTTCGCCGCTGCGCAGCGCCGACCTCGAG
CTTGAACGCGTGCACGACGAGCTGCCGTGA

Structures

Antitoxin

• AlphaFold DB: U4SMI8