Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1297154..1297931 Replicon chromosome
Accession NZ_CP049090
Organism Glaesserella parasuis strain aHPS7

Toxin (Protein)


Gene name TacT3 Uniprot ID B8F4U7
Locus tag G5S31_RS06240 Protein ID WP_005710654.1
Coordinates 1297431..1297931 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag G5S31_RS06235 Protein ID WP_005710653.1
Coordinates 1297154..1297441 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S31_RS06215 1293521..1294021 - 501 WP_016527798.1 CvpA family protein -
G5S31_RS06220 1294126..1295703 - 1578 WP_026916904.1 FAD-binding protein -
G5S31_RS06225 1295878..1296615 - 738 WP_044009509.1 peptidoglycan editing factor PgeF -
G5S31_RS06230 1296619..1297008 - 390 WP_035519839.1 RidA family protein -
G5S31_RS06235 1297154..1297441 + 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
G5S31_RS06240 1297431..1297931 + 501 WP_005710654.1 GNAT family N-acetyltransferase Toxin
G5S31_RS06245 1297959..1298960 + 1002 WP_005710656.1 nucleoid-associated protein YejK -
G5S31_RS06250 1299021..1299356 + 336 WP_010786648.1 outer membrane protein assembly factor BamE -
G5S31_RS06255 1299511..1300626 + 1116 WP_035519838.1 anhydro-N-acetylmuramic acid kinase -
G5S31_RS06260 1300638..1301552 + 915 WP_082259327.1 N-acetylmuramic acid 6-phosphate etherase -
G5S31_RS06265 1301594..1301908 + 315 WP_005710664.1 YqcC family protein -
G5S31_RS06270 1301905..1302633 + 729 WP_021115014.1 tRNA pseudouridine(65) synthase TruC -
G5S31_RS06275 1302651..1302806 + 156 WP_005710668.1 YoaH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19184.39 Da        Isoelectric Point: 9.3198

>T150469 WP_005710654.1 NZ_CP049090:1297431-1297931 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T150469 NZ_CP064686:c1872017-1871592 [Bradyrhizobium sp. 4]
GTGAATCTACTGCTCGACACCAACGTGTTGTCGGAGGTCCAGAGGCCGGCCCCTTCGCCGAAAGTCCTGTCATGGCTTGA
TACGATCGACGAGGATCGTGCGTTCATCAGCGTGGCATCGATCGCCGAGCTTCGCCGCGGCATCGCATTGCTGGAGGACG
GCCGTCGGCGCGCAGCACTGGCCGCCTGGCTTGCCCACGATCTGCCGGAGCGTTTTGCCGGGCGTACCCTGTCGATCGAC
CACGCGGTGGCCGAACGCTGGGGTGACCTGATGGCTCAGAGCCGCAGAAGCGGCGTCGCATTGTCTGTCATGGACGGCTT
CTTTGCCGCGACCGCTCTCGCGAACAACCTCATGCTCGTCACGCGCAATGTGACGGATTTCGCGGTGTTCGGCGTCCCGC
TGCTGAACCCGTGGGACAACCCATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT150469 WP_005710653.1 NZ_CP049090:1297154-1297441 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT150469 NZ_CP064686:c1872295-1872014 [Bradyrhizobium sp. 4]
ATGACAGATAACAGCACTGCACCAGAGTCACCTGCGACCGACTCGTGGACGCTTGCCAACGCCAAGGCCCGGCTATCCGA
GGTGATCGACCGTGCTCAAGCCGGCCCGCAAATCATCACCCGACACGGCAAGCCCAATGCGGTGATCGTTTCTGCCGAGG
AATGGGCGCGCAAGACGGCACGTAAAGGTACCTTGGCCGAATTCCTGCTGGCTTCGCCGCTGCGCAGCGCCGACCTCGAG
CTTGAACGCGTGCACGACGCGCCGCACGACGAGCTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZP3

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References