Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 651288..651823 Replicon chromosome
Accession NZ_CP049090
Organism Glaesserella parasuis strain aHPS7

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag G5S31_RS03295 Protein ID WP_010785923.1
Coordinates 651539..651823 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag G5S31_RS03290 Protein ID WP_021118772.1
Coordinates 651288..651542 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S31_RS03270 646844..647386 + 543 WP_010785927.1 adenine phosphoribosyltransferase -
G5S31_RS03275 647474..649492 + 2019 WP_021118771.1 DNA polymerase III subunit gamma/tau -
G5S31_RS03280 649498..650394 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
G5S31_RS03285 650416..651171 + 756 WP_021112098.1 ABC transporter permease -
G5S31_RS03290 651288..651542 + 255 WP_021118772.1 hypothetical protein Antitoxin
G5S31_RS03295 651539..651823 + 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5S31_RS03300 652033..653583 + 1551 WP_010785922.1 exodeoxyribonuclease I -
G5S31_RS03305 653666..654625 + 960 WP_160404628.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
G5S31_RS03310 654774..655595 + 822 WP_160404629.1 PHP domain-containing protein -
G5S31_RS03315 655702..656193 - 492 WP_005712683.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T150466 WP_010785923.1 NZ_CP049090:651539-651823 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T150466 NZ_CP064684:6089691-6090116 [Bradyrhizobium sp. CW1]
GTGAATCTACTGCTCGACACCAACGTGTTGTCGGAGGTCCAGAGGCCCGCCCCTTCGCCGAAAGTCTTGTCATGGCTTGA
TACGATCGACGAGGATCGTGCGTTCATCAGCGCGGCATCGATCGCCGAGCTTCGTCGCGGCATCGCGTTGCTGGAGGACG
GCCGTCGCCGTGCAGCACTGGCCGCCTGGCTTGCCCGCGATCTGCCGGAGCGTTTTGCCGGGCGCACACTGCCGATCGAC
CACGCGGTCGCGGAACGCTGGGGTGACCTGATGGCTCAGAGTCGCAGAAGCGGTCTCGCATTGTCTGTCATGGACGGCTT
CTTTGCCGCGACCGCGCTGGCAAACAACCTCATGCTCGTCACGCGCAATGTGAAGGATTTTGCGGTATTCGGCGTGCCGC
TGCTGAACCCGTGGGACAACCCATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT150466 WP_021118772.1 NZ_CP049090:651288-651542 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT150466 NZ_CP064684:6089416-6089694 [Bradyrhizobium sp. CW1]
ATGACGGAACACACTGCACCAGATTCACCAGCGACGGACTCGTGGACGCTTGCCAACGCCAAGGCCCGGCTCTCCGAGGT
GATCGATCGTGCCCAAGCCGGCCCGCAAATCATCACCCGACACGGCAAGCCCAACGCGGTGATCGTTTCCGTCGAGGAAT
GGGCGCGCAAGACGGCGCGCAAAGGTACCTTGGCCGAATTCCTGCTGGCTTCGCCGCTGCGCAGCGGCGACCTCGAGCTT
GAACGCGTTCACGACGCGCCGCACGACGAGCTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References