Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 566245..566825 Replicon chromosome
Accession NZ_CP049090
Organism Glaesserella parasuis strain aHPS7

Toxin (Protein)


Gene name mazF Uniprot ID A0A143CFE3
Locus tag G5S31_RS02895 Protein ID WP_005710599.1
Coordinates 566245..566589 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U4SAI4
Locus tag G5S31_RS02900 Protein ID WP_005710601.1
Coordinates 566586..566825 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S31_RS02885 564167..565558 - 1392 WP_164689388.1 MATE family efflux transporter -
G5S31_RS02890 565571..566239 - 669 WP_021118711.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
G5S31_RS02895 566245..566589 - 345 WP_005710599.1 endoribonuclease MazF Toxin
G5S31_RS02900 566586..566825 - 240 WP_005710601.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G5S31_RS02905 567011..567886 + 876 WP_021119465.1 putative selenate ABC transporter substrate-binding protein -
G5S31_RS02910 567995..568747 + 753 WP_102033221.1 phosphonate ABC transporter ATP-binding protein -
G5S31_RS02915 568737..569522 + 786 WP_021118713.1 ABC transporter permease subunit -
G5S31_RS02920 569519..570367 + 849 WP_075592852.1 ABC transporter permease subunit -
G5S31_RS02925 570438..571130 + 693 WP_021114597.1 tellurite resistance TerB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12830.81 Da        Isoelectric Point: 7.9277

>T150465 WP_005710599.1 NZ_CP049090:c566589-566245 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPTIYNRQTGLLICCPLTTKVKGYPFEVNIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE

Download         Length: 345 bp

>T150465 NZ_CP064682:c4569658-4569317 [Escherichia coli K-12]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8782.21 Da        Isoelectric Point: 5.0351

>AT150465 WP_005710601.1 NZ_CP049090:c566825-566586 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML

Download         Length: 240 bp

>AT150465 NZ_CP064682:4569653-4569729 [Escherichia coli K-12]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143CFE3

Antitoxin

Source ID Structure
AlphaFold DB U4SAI4

References