Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 330115..330754 Replicon chromosome
Accession NZ_CP049090
Organism Glaesserella parasuis strain aHPS7

Toxin (Protein)


Gene name relE Uniprot ID A0A8A2WDH5
Locus tag G5S31_RS01680 Protein ID WP_021110906.1
Coordinates 330115..330450 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G5S31_RS01685 Protein ID WP_164681833.1
Coordinates 330458..330754 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S31_RS01650 326102..327070 + 969 Protein_322 transposase -
G5S31_RS01655 327263..328003 - 741 Protein_323 transposase -
G5S31_RS01660 328202..328672 - 471 WP_021110902.1 hypothetical protein -
G5S31_RS01665 328748..329032 - 285 WP_148122864.1 hypothetical protein -
G5S31_RS01670 329126..329437 - 312 WP_042906459.1 hypothetical protein -
G5S31_RS01675 329552..329956 - 405 WP_021110905.1 DNA polymerase III subunit psi -
G5S31_RS01680 330115..330450 + 336 WP_021110906.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5S31_RS01685 330458..330754 + 297 WP_164681833.1 putative addiction module antidote protein Antitoxin
G5S31_RS01690 330827..331816 + 990 WP_160405624.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
G5S31_RS01695 331917..333048 + 1132 Protein_331 IS3 family transposase -
G5S31_RS01700 333076..333405 - 330 Protein_332 transposase -
G5S31_RS01705 333586..334023 + 438 WP_164689363.1 IS1 family transposase -
G5S31_RS01710 334520..335707 - 1188 WP_164689365.1 elongation factor Tu -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 323213..333405 10192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-93)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12209.91 Da        Isoelectric Point: 9.5918

>T150464 WP_021110906.1 NZ_CP049090:330115-330450 [Glaesserella parasuis]
MSGIINQIIITDNFSKWLDGLKNPIAKATVARRIKNTVKGNFDDHKALAGTGGLYEMRIATGAGYRIYYAQQGDVIYILL
QGGDKSTQQVDIEKAKALWAELKQTGGSNEY

Download         Length: 336 bp

>T150464 NZ_CP064682:c4523870-4523613 [Escherichia coli K-12]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10948.49 Da        Isoelectric Point: 4.8951

>AT150464 WP_164681833.1 NZ_CP049090:330458-330754 [Glaesserella parasuis]
MAEKHGLRPFDVAEFLDNEETIQAYLAEVLKEGDQDEFLEALNDVARARGIAELAKQTGLGRESLYKTLSKGSKPRFETI
QKILGAFNLVLIPQIKNS

Download         Length: 297 bp

>AT150464 NZ_CP064682:c4523601-4523056 [Escherichia coli K-12]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References