Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1984439..1985045 Replicon chromosome
Accession NZ_CP049089
Organism Glaesserella parasuis strain vHPS7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag G5C67_RS09710 Protein ID WP_021114171.1
Coordinates 1984439..1984756 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G5C67_RS09715 Protein ID WP_021114170.1
Coordinates 1984758..1985045 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C67_RS09685 1981251..1982108 - 858 WP_075630627.1 DUF1837 domain-containing protein -
G5C67_RS09690 1982159..1982350 - 192 Protein_1860 ATPase -
G5C67_RS09695 1982489..1983057 - 569 Protein_1861 efflux RND transporter permease subunit -
G5C67_RS09700 1983342..1983866 - 525 WP_157888936.1 efflux RND transporter permease subunit -
G5C67_RS09705 1983824..1984222 - 399 WP_075630625.1 efflux RND transporter permease subunit -
G5C67_RS09710 1984439..1984756 + 318 WP_021114171.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5C67_RS09715 1984758..1985045 + 288 WP_021114170.1 putative addiction module antidote protein Antitoxin
G5C67_RS09720 1985312..1986270 - 959 Protein_1866 efflux RND transporter periplasmic adaptor subunit -
G5C67_RS09725 1986465..1987535 - 1071 WP_075630643.1 restriction endonuclease subunit S -
G5C67_RS09730 1987556..1989600 - 2045 Protein_1868 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11965.65 Da        Isoelectric Point: 9.3816

>T150461 WP_021114171.1 NZ_CP049089:1984439-1984756 [Glaesserella parasuis]
MNVIETTLIFDEWLDNLKDLRAKIQIVTRIRRAENGNFGDHKPLPNTGGVSEIRLDIGKGYRIYYGQIGEITYILTNGGD
KSSQQADIEKAKALFVQIKQQKKEQ

Download         Length: 318 bp

>T150461 NZ_CP064682:c3693447-3693340 [Escherichia coli K-12]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10484.04 Da        Isoelectric Point: 5.0489

>AT150461 WP_021114170.1 NZ_CP049089:1984758-1985045 [Glaesserella parasuis]
MIETNRFDIVKYLDSDEAIAIYLTQIAETGDSNDFIVALGDVARAKGIAEIAQKTGLARESIYKALTSGSKPRFDTIMRI
MNALNLKPQYAINLS

Download         Length: 288 bp

>AT150461 NZ_CP064682:3693496-3693562 [Escherichia coli K-12]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References