Detailed information of TA system TA150459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1800411..1801050
• Replicon: chromosome
• Accession: NZ_CP049089
• Organism: Glaesserella parasuis strain vHPS7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6I4QYS7
• Locus tag: G5C67_RS08835
• Protein ID: WP_021114433.1
• Coordinates: 1800411..1800746 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G5C67_RS08840
• Protein ID: WP_164681833.1
• Coordinates: 1800754..1801050 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5C67_RS08800	1796141..1796470	-	330	WP_021113605.1	hypothetical protein	-
G5C67_RS08805	1796612..1797184	+	573	WP_035522608.1	sigma-70 family RNA polymerase sigma factor	-
G5C67_RS08810	1797181..1797366	+	186	WP_005713975.1	zf-HC2 domain-containing protein	-
G5C67_RS08815	1797555..1798298	-	744	Protein_1698	transposase	-
G5C67_RS08820	1798390..1799328	-	939	WP_160427824.1	oligoendopeptidase F family protein	-
G5C67_RS08825	1799422..1799733	-	312	WP_042906459.1	hypothetical protein	-
G5C67_RS08830	1799848..1800252	-	405	WP_021110905.1	DNA polymerase III subunit psi	-
G5C67_RS08835	1800411..1800746	+	336	WP_021114433.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G5C67_RS08840	1800754..1801050	+	297	WP_164681833.1	putative addiction module antidote protein	Antitoxin
G5C67_RS08845	1801123..1802112	+	990	WP_021116485.1	16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC	-
G5C67_RS08850	1802213..1803339	+	1127	Protein_1705	IS3 family transposase	-
G5C67_RS08855	1803367..1803696	-	330	Protein_1706	IS5 family transposase	-
G5C67_RS08860	1804084..1804672	+	589	Protein_1707	transposase	-
G5C67_RS08865	1804809..1805996	-	1188	WP_016527483.1	elongation factor Tu	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1792306..1803696	11390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-96)

Antitoxin

• Uncharacterized protein HI1420 (9-91)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12079.77 Da
• Isoelectric Point: 9.8168

>T150459 WP_021114433.1 NZ_CP049089:1800411-1800746 [Glaesserella parasuis]
MSGIINQIVITDNFSKWLDGLKNPIAKATVARRIKNAVKGNFGDHKALAGTGGLYEMRIATGAGYRIYYAQQGDVIYILL
QGGDKSTQQADIEKAKALWAELKQTGGSNEY

Nucleotide

• Length: 336 bp

>T150459 NZ_CP064682:c3227814-3227500 [Escherichia coli K-12]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10948.49 Da
• Isoelectric Point: 4.8951

>AT150459 WP_164681833.1 NZ_CP049089:1800754-1801050 [Glaesserella parasuis]
MAEKHGLRPFDVAEFLDNEETIQAYLAEVLKEGDQDEFLEALNDVARARGIAELAKQTGLGRESLYKTLSKGSKPRFETI
QKILGAFNLVLIPQIKNS

Nucleotide

• Length: 297 bp

>AT150459 NZ_CP064682:c3227503-3227087 [Escherichia coli K-12]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: A0A6I4QYS7