Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1587253..1587833 Replicon chromosome
Accession NZ_CP049089
Organism Glaesserella parasuis strain vHPS7

Toxin (Protein)


Gene name mazF Uniprot ID A0A836MFL2
Locus tag G5C67_RS07765 Protein ID WP_021114594.1
Coordinates 1587489..1587833 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U4SAI4
Locus tag G5C67_RS07760 Protein ID WP_005710601.1
Coordinates 1587253..1587492 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C67_RS07735 1582957..1583649 - 693 WP_021118715.1 tellurite resistance TerB family protein -
G5C67_RS07740 1583711..1584559 - 849 WP_042905731.1 ABC transporter permease subunit -
G5C67_RS07745 1584556..1585341 - 786 WP_075630388.1 ABC transporter permease subunit -
G5C67_RS07750 1585331..1586080 - 750 WP_075630389.1 phosphonate ABC transporter ATP-binding protein -
G5C67_RS07755 1586192..1587067 - 876 WP_075630390.1 putative selenate ABC transporter substrate-binding protein -
G5C67_RS07760 1587253..1587492 + 240 WP_005710601.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G5C67_RS07765 1587489..1587833 + 345 WP_021114594.1 endoribonuclease MazF Toxin
G5C67_RS07770 1587839..1588507 + 669 WP_021118711.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
G5C67_RS07775 1588520..1589911 + 1392 WP_010785980.1 MATE family efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12801.77 Da        Isoelectric Point: 7.3830

>T150457 WP_021114594.1 NZ_CP049089:1587489-1587833 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPAIYNRQTGLLICCPLTTKVKGYPFEVDIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE

Download         Length: 345 bp

>T150457 NZ_CP064682:c3034182-3033775 [Escherichia coli K-12]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8782.21 Da        Isoelectric Point: 5.0351

>AT150457 WP_005710601.1 NZ_CP049089:1587253-1587492 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML

Download         Length: 240 bp

>AT150457 NZ_CP064682:c3034429-3034163 [Escherichia coli K-12]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836MFL2

Antitoxin

Source ID Structure
AlphaFold DB U4SAI4

References