Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1503443..1503978 Replicon chromosome
Accession NZ_CP049089
Organism Glaesserella parasuis strain vHPS7

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag G5C67_RS07370 Protein ID WP_010785923.1
Coordinates 1503443..1503727 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag G5C67_RS07375 Protein ID WP_021118772.1
Coordinates 1503724..1503978 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C67_RS07350 1499072..1499563 + 492 WP_005712683.1 acetolactate synthase small subunit -
G5C67_RS07355 1499670..1500491 - 822 WP_005712684.1 PHP domain-containing protein -
G5C67_RS07360 1500640..1501599 - 960 WP_005712686.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
G5C67_RS07365 1501682..1503232 - 1551 WP_010785922.1 exodeoxyribonuclease I -
G5C67_RS07370 1503443..1503727 - 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5C67_RS07375 1503724..1503978 - 255 WP_021118772.1 hypothetical protein Antitoxin
G5C67_RS07380 1504095..1504850 - 756 WP_021112098.1 ABC transporter permease -
G5C67_RS07385 1504872..1505768 - 897 WP_005712691.1 ABC transporter ATP-binding protein -
G5C67_RS07390 1505774..1507792 - 2019 WP_071610083.1 DNA polymerase III subunit gamma/tau -
G5C67_RS07395 1507881..1508423 - 543 WP_010785927.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T150456 WP_010785923.1 NZ_CP049089:c1503727-1503443 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T150456 NZ_CP064682:c2904450-2904115 [Escherichia coli K-12]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT150456 WP_021118772.1 NZ_CP049089:c1503978-1503724 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT150456 NZ_CP064682:c2904698-2904450 [Escherichia coli K-12]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References