Detailed information of TA system TA150444

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 125975..126752
• Replicon: chromosome
• Accession: NZ_CP049088
• Organism: Glaesserella parasuis strain sHPS7

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: G5C59_RS00700
• Protein ID: WP_021118351.1
• Coordinates: 126252..126752 (+)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: G5C59_RS00695
• Protein ID: WP_005710653.1
• Coordinates: 125975..126262 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5C59_RS00675	122343..122843	-	501	WP_021115009.1	CvpA family protein	-
G5C59_RS00680	122947..124524	-	1578	WP_021118349.1	FAD-binding protein	-
G5C59_RS00685	124699..125436	-	738	WP_021118350.1	peptidoglycan editing factor PgeF	-
G5C59_RS00690	125440..125829	-	390	WP_016527795.1	RidA family protein	-
G5C59_RS00695	125975..126262	+	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
G5C59_RS00700	126252..126752	+	501	WP_021118351.1	GNAT family N-acetyltransferase	Toxin
G5C59_RS00705	126780..127781	+	1002	WP_010786647.1	nucleoid-associated protein YejK	-
G5C59_RS00710	127842..128177	+	336	WP_016527793.1	outer membrane protein assembly factor BamE	-
G5C59_RS00715	128331..129446	+	1116	WP_016527792.1	anhydro-N-acetylmuramic acid kinase	-
G5C59_RS00720	129458..130372	+	915	WP_021118353.1	N-acetylmuramic acid 6-phosphate etherase	-
G5C59_RS00725	130414..130728	+	315	WP_005710664.1	YqcC family protein	-
G5C59_RS00730	130725..131453	+	729	WP_021112446.1	tRNA pseudouridine(65) synthase TruC	-
G5C59_RS00735	131471..131626	+	156	WP_021116533.1	YoaH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19097.26 Da
• Isoelectric Point: 9.2835

>T150444 WP_021118351.1 NZ_CP049088:126252-126752 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYSRQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T150444 NZ_CP064682:c1265266-1265159 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT150444 WP_005710653.1 NZ_CP049088:125975-126262 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT150444 NZ_CP064682:1265313-1265379 [Escherichia coli K-12]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: U4SPD7