Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4412150..4412985 Replicon chromosome
Accession NZ_CP049085
Organism Escherichia coli strain p4A

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag G6P91_RS21685 Protein ID WP_000854759.1
Coordinates 4412150..4412527 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag G6P91_RS21690 Protein ID WP_001295723.1
Coordinates 4412617..4412985 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P91_RS21655 4408088..4408264 - 177 Protein_4251 helix-turn-helix domain-containing protein -
G6P91_RS21660 4408456..4409202 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
G6P91_RS21665 4409217..4410758 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
G6P91_RS21670 4411214..4411372 - 159 WP_001467148.1 hypothetical protein -
G6P91_RS21675 4411472..4411648 - 177 WP_000839286.1 DUF957 domain-containing protein -
G6P91_RS21680 4411665..4412153 - 489 WP_000761690.1 hypothetical protein -
G6P91_RS21685 4412150..4412527 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
G6P91_RS21690 4412617..4412985 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G6P91_RS21695 4413148..4413369 - 222 WP_000692345.1 DUF987 domain-containing protein -
G6P91_RS21700 4413432..4413908 - 477 WP_001186775.1 RadC family protein -
G6P91_RS21705 4413924..4414397 - 474 WP_001350782.1 antirestriction protein -
G6P91_RS21710 4414739..4415557 - 819 WP_001234738.1 DUF945 domain-containing protein -
G6P91_RS21715 4415712..4415870 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T150438 WP_000854759.1 NZ_CP049085:c4412527-4412150 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T150438 NZ_CP064681:c4569664-4569323 [Escherichia coli K-12]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT150438 WP_001295723.1 NZ_CP049085:c4412985-4412617 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT150438 NZ_CP064681:4569659-4569735 [Escherichia coli K-12]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References