Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 955308..955962 Replicon chromosome
Accession NZ_CP049085
Organism Escherichia coli strain p4A

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag G6P91_RS04645 Protein ID WP_000244765.1
Coordinates 955555..955962 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag G6P91_RS04640 Protein ID WP_000354050.1
Coordinates 955308..955574 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P91_RS04620 951396..952829 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
G6P91_RS04625 952874..953185 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
G6P91_RS04630 953349..954008 + 660 WP_000250275.1 hemolysin III family protein -
G6P91_RS04635 954085..955065 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
G6P91_RS04640 955308..955574 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
G6P91_RS04645 955555..955962 + 408 WP_000244765.1 protein YgfX Toxin
G6P91_RS04650 956002..956523 - 522 WP_001055874.1 flavodoxin FldB -
G6P91_RS04655 956635..957531 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G6P91_RS04660 957556..958266 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G6P91_RS04665 958272..960005 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T150420 WP_000244765.1 NZ_CP049085:955555-955962 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T150420 NZ_CP064681:1503543-1503719 [Escherichia coli K-12]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT150420 WP_000354050.1 NZ_CP049085:955308-955574 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150420 NZ_CP064681:1503765-1504181 [Escherichia coli K-12]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References