Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4750293..4751094 Replicon chromosome
Accession NZ_CP049077
Organism Escherichia coli strain p11A

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag G6P89_RS23475 Protein ID WP_001094436.1
Coordinates 4750717..4751094 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag G6P89_RS23470 Protein ID WP_015953067.1
Coordinates 4750293..4750670 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P89_RS23435 4746204..4746884 + 681 WP_001282919.1 WYL domain-containing protein -
G6P89_RS23440 4747032..4747709 + 678 WP_001097301.1 hypothetical protein -
G6P89_RS23445 4747715..4747948 + 234 WP_001278287.1 DUF905 family protein -
G6P89_RS23450 4748038..4748856 + 819 WP_001175163.1 DUF945 domain-containing protein -
G6P89_RS23455 4748948..4749433 + 486 WP_029700724.1 antirestriction protein -
G6P89_RS23460 4749448..4749924 + 477 WP_001186756.1 RadC family protein -
G6P89_RS23465 4749993..4750214 + 222 WP_000692312.1 DUF987 domain-containing protein -
G6P89_RS23470 4750293..4750670 + 378 WP_015953067.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
G6P89_RS23475 4750717..4751094 + 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
G6P89_RS23480 4751091..4751579 + 489 WP_000761714.1 hypothetical protein -
G6P89_RS23485 4751591..4751788 + 198 WP_000839254.1 DUF957 domain-containing protein -
G6P89_RS23490 4751873..4752568 + 696 Protein_4612 DUF4942 domain-containing protein -
G6P89_RS23495 4752632..4753387 - 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -
G6P89_RS23500 4753384..4753710 - 327 Protein_4614 IS21 family transposase -
G6P89_RS23505 4753741..4755354 - 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
G6P89_RS23510 4755385..4755735 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T150374 WP_001094436.1 NZ_CP049077:4750717-4751094 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

>T150374 NZ_CP064679:2770812-2771141 [Escherichia coli K-12]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT150374 WP_015953067.1 NZ_CP049077:4750293-4750670 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT150374 NZ_CP064679:2770474-2770791 [Escherichia coli K-12]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References