Detailed information of TA system TA150371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4414471..4415291
• Replicon: chromosome
• Accession: NZ_CP049077
• Organism: Escherichia coli strain p11A

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: G6P89_RS21800
• Protein ID: WP_001054379.1
• Coordinates: 4414471..4414728 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: G6P89_RS21805
• Protein ID: WP_000123957.1
• Coordinates: 4414740..4415291 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6P89_RS21780	4410018..4410998	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
G6P89_RS21785	4411581..4412687	-	1107	Protein_4276	DNA helicase	-
G6P89_RS21790	4412750..4413897	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
G6P89_RS21795	4413930..4414094	+	165	Protein_4278	GNAT family N-acetyltransferase	-
G6P89_RS21800	4414471..4414728	+	258	WP_001054379.1	YjhX family toxin	Toxin
G6P89_RS21805	4414740..4415291	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
G6P89_RS21810	4415343..4416089	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
G6P89_RS21815	4416217..4416477	+	261	WP_000077645.1	hypothetical protein	-
G6P89_RS21820	4416515..4416631	+	117	Protein_4283	VOC family protein	-
G6P89_RS21825	4416876..4417997	+	1122	WP_000010833.1	M42 family metallopeptidase	-
G6P89_RS21830	4417994..4418272	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
G6P89_RS21835	4418284..4419597	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	4403092..4423512	20420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T150371 WP_001054379.1 NZ_CP049077:4414471-4414728 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T150371 NZ_CP064679:c2082946-2082692 [Escherichia coli K-12]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT150371 WP_000123957.1 NZ_CP049077:4414740-4415291 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT150371 NZ_CP064679:c2083194-2082943 [Escherichia coli K-12]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: B6I030