Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1984926..1985757 | Replicon | chromosome |
| Accession | NZ_CP049077 | ||
| Organism | Escherichia coli strain p11A | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | G6P89_RS09490 | Protein ID | WP_165696580.1 |
| Coordinates | 1984926..1985300 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A061Y7A8 |
| Locus tag | G6P89_RS09495 | Protein ID | WP_001280918.1 |
| Coordinates | 1985389..1985757 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6P89_RS09450 | 1980322..1981488 | + | 1167 | WP_001296209.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| G6P89_RS09455 | 1981607..1982080 | + | 474 | WP_001105368.1 | DNA gyrase inhibitor SbmC | - |
| G6P89_RS09460 | 1982278..1983336 | + | 1059 | WP_001200889.1 | FUSC family protein | - |
| G6P89_RS09465 | 1983508..1983837 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| G6P89_RS09470 | 1983938..1984120 | - | 183 | WP_001296208.1 | hypothetical protein | - |
| G6P89_RS09475 | 1984174..1984320 | + | 147 | Protein_1858 | transposase domain-containing protein | - |
| G6P89_RS09480 | 1984609..1984722 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| G6P89_RS09485 | 1984735..1984929 | - | 195 | WP_000988600.1 | hypothetical protein | - |
| G6P89_RS09490 | 1984926..1985300 | - | 375 | WP_165696580.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| G6P89_RS09495 | 1985389..1985757 | - | 369 | WP_001280918.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| G6P89_RS09500 | 1985773..1986417 | - | 645 | WP_000086752.1 | hypothetical protein | - |
| G6P89_RS09505 | 1986436..1986657 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| G6P89_RS09510 | 1986720..1987196 | - | 477 | WP_001186200.1 | RadC family protein | - |
| G6P89_RS09515 | 1987212..1987685 | - | 474 | WP_001542276.1 | antirestriction protein | - |
| G6P89_RS09520 | 1987779..1988024 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| G6P89_RS09525 | 1988024..1988842 | - | 819 | WP_001542275.1 | DUF945 domain-containing protein | - |
| G6P89_RS09530 | 1989063..1989473 | - | 411 | WP_000846703.1 | hypothetical protein | - |
| G6P89_RS09535 | 1989489..1989839 | - | 351 | Protein_1870 | hypothetical protein | - |
| G6P89_RS09540 | 1989922..1990668 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1938275..1993958 | 55683 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13813.79 Da Isoelectric Point: 7.1326
>T150356 WP_165696580.1 NZ_CP049077:c1985300-1984926 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDIPRARRATGLMTSDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDIPRARRATGLMTSDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T150356 NZ_CP064678:c4523871-4523614 [Escherichia coli K-12]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13811.70 Da Isoelectric Point: 6.4767
>AT150356 WP_001280918.1 NZ_CP049077:c1985757-1985389 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT150356 NZ_CP064678:c4523602-4523057 [Escherichia coli K-12]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|