Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 807213..808047 Replicon chromosome
Accession NZ_CP049077
Organism Escherichia coli strain p11A

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag G6P89_RS03880 Protein ID WP_000854690.1
Coordinates 807213..807590 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag G6P89_RS03885 Protein ID WP_001305076.1
Coordinates 807679..808047 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6P89_RS03850 803607..803762 - 156 WP_000729638.1 hypothetical protein -
G6P89_RS03855 804194..805127 - 934 Protein_757 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
G6P89_RS03860 805120..805515 - 396 WP_000208384.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
G6P89_RS03865 805584..806429 - 846 WP_001529401.1 DUF4942 domain-containing protein -
G6P89_RS03870 806514..806711 - 198 WP_000839293.1 DUF957 domain-containing protein -
G6P89_RS03875 806728..807216 - 489 WP_000761699.1 hypothetical protein -
G6P89_RS03880 807213..807590 - 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
G6P89_RS03885 807679..808047 - 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G6P89_RS03890 808097..808741 - 645 WP_000094916.1 hypothetical protein -
G6P89_RS03895 808760..808981 - 222 WP_000692329.1 DUF987 domain-containing protein -
G6P89_RS03900 809044..809520 - 477 WP_001186726.1 RadC family protein -
G6P89_RS03905 809536..810021 - 486 WP_000849565.1 antirestriction protein -
G6P89_RS03910 810076..810894 - 819 WP_001234620.1 DUF945 domain-containing protein -
G6P89_RS03915 810995..811228 - 234 WP_000902034.1 DUF905 family protein -
G6P89_RS03920 811307..811762 - 456 WP_000581502.1 hypothetical protein -
G6P89_RS03925 811838..812965 - 1128 Protein_771 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF 785596..810021 24425
- flank IS/Tn - - 803607..803762 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T150353 WP_000854690.1 NZ_CP049077:c807590-807213 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T150353 NZ_CP064678:c3693448-3693341 [Escherichia coli K-12]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT150353 WP_001305076.1 NZ_CP049077:c808047-807679 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT150353 NZ_CP064678:3693497-3693563 [Escherichia coli K-12]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PLF5

Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References