Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3694321..3694937 Replicon chromosome
Accession NZ_CP049046
Organism Enterobacter hormaechei strain Y233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G5B34_RS17635 Protein ID WP_015569913.1
Coordinates 3694321..3694692 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag G5B34_RS17640 Protein ID WP_015569912.1
Coordinates 3694695..3694937 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5B34_RS17620 3691821..3692723 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
G5B34_RS17625 3692720..3693355 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
G5B34_RS17630 3693352..3694281 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
G5B34_RS17635 3694321..3694692 - 372 WP_015569913.1 PIN domain-containing protein Toxin
G5B34_RS17640 3694695..3694937 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
G5B34_RS17645 3695136..3696056 + 921 WP_015569911.1 alpha/beta hydrolase -
G5B34_RS17650 3696065..3697006 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
G5B34_RS17655 3697051..3697488 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
G5B34_RS17660 3697485..3698366 - 882 WP_003861949.1 virulence factor BrkB family protein -
G5B34_RS17665 3698360..3698959 - 600 WP_003861947.1 glucose-1-phosphatase -
G5B34_RS17670 3699078..3699878 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T150337 WP_015569913.1 NZ_CP049046:c3694692-3694321 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T150337 NZ_CP064678:c1265801-1265694 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT150337 WP_015569912.1 NZ_CP049046:c3694937-3694695 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT150337 NZ_CP064678:1265848-1265914 [Escherichia coli K-12]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References