Detailed information of TA system TA150317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 20412..20967
• Replicon: plasmid pRR4-35_2
• Accession: NZ_CP049039
• Organism: Pseudohalocynthiibacter aestuariivivens strain RR4-35

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G5B38_RS19660
• Protein ID: WP_165198350.1
• Coordinates: 20412..20735 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: G5B38_RS19665
• Protein ID: WP_165198351.1
• Coordinates: 20722..20967 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5B38_RS19640	15576..16637	-	1062	WP_165198345.1	TniQ family protein	-
G5B38_RS19645	16634..17578	-	945	WP_165198346.1	TniB family NTP-binding protein	-
G5B38_RS19650	17569..19215	-	1647	WP_165198348.1	DDE-type integrase/transposase/recombinase	-
G5B38_RS19655	19316..20407	+	1092	WP_206295799.1	tyrosine-type recombinase/integrase	-
G5B38_RS19660	20412..20735	-	324	WP_165198350.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G5B38_RS19665	20722..20967	-	246	WP_165198351.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G5B38_RS19670	21089..21970	+	882	WP_165198352.1	recombinase family protein	-
G5B38_RS19675	22253..23440	+	1188	WP_165198353.1	plasmid partitioning protein RepA	-
G5B38_RS19680	23440..24510	+	1071	WP_165198355.1	plasmid partitioning protein RepB	-
G5B38_RS19685	24666..25715	+	1050	WP_165198356.1	replication protein C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..140737	140737

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-94)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12132.68 Da
• Isoelectric Point: 4.6761

>T150317 WP_165198350.1 NZ_CP049039:c20735-20412 [Pseudohalocynthiibacter aestuariivivens]
MPADRGWTVRPAAETDLSDIWIYGSDTLGIDQADRYTDGLFALFGLLAEFPEMARERTEFSPPVRIHSSGKHLAVYQITG
QRVEIIRILHARQDLRAYLMEADGPQE

Nucleotide

• Length: 324 bp

>T150317 NZ_CP064672:4594425-4594736 [Salmonella sp. SJTUF14146]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9289.51 Da
• Isoelectric Point: 10.5182

>AT150317 WP_165198351.1 NZ_CP049039:c20967-20722 [Pseudohalocynthiibacter aestuariivivens]
MGTMNISLPDPMKSWVEDQTKAGRYANSSDYVRDLIRRDRARQEAISELQAEIDRGLASGPAKRLDQQAFKSVMRSKYAR
R

Nucleotide

• Length: 246 bp

>AT150317 NZ_CP064672:4594733-4595179 [Salmonella sp. SJTUF14146]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG