Detailed information of TA system TA150310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3081291..3081896
• Replicon: chromosome
• Accession: NZ_CP049021
• Organism: Enterobacter hormaechei strain Eho-E3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: GVI75_RS14840
• Protein ID: WP_012906750.1
• Coordinates: 3081291..3081470 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A822X3T2
• Locus tag: GVI75_RS14845
• Protein ID: WP_032619507.1
• Coordinates: 3081492..3081896 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVI75_RS14815	3076620..3077336	+	717	WP_032619512.1	ABC transporter ATP-binding protein	-
GVI75_RS14820	3077502..3077972	+	471	WP_017384432.1	hypothetical protein	-
GVI75_RS14825	3077978..3078904	-	927	WP_032619511.1	LysR family transcriptional regulator	-
GVI75_RS14830	3078934..3079257	-	324	WP_017384434.1	hypothetical protein	-
GVI75_RS14835	3079260..3080015	-	756	Protein_2909	DUF4225 domain-containing protein	-
GVI75_RS14840	3081291..3081470	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
GVI75_RS14845	3081492..3081896	+	405	WP_032619507.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GVI75_RS14850	3081937..3083007	-	1071	WP_032635096.1	glycosyltransferase family 9 protein	-
GVI75_RS14855	3083084..3083662	-	579	WP_032619505.1	tail fiber assembly protein	-
GVI75_RS14860	3083662..3085839	-	2178	WP_058670599.1	phage tail protein	-
GVI75_RS14865	3085842..3086393	-	552	WP_032619504.1	phage tail protein I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliA	3076632..3186306	109674

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T150310 WP_012906750.1 NZ_CP049021:3081291-3081470 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T150310 NZ_CP064672:c1083355-1082828 [Salmonella sp. SJTUF14146]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTAGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14676.53 Da
• Isoelectric Point: 4.2136

>AT150310 WP_032619507.1 NZ_CP049021:3081492-3081896 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Nucleotide

• Length: 405 bp

>AT150310 NZ_CP064672:c1083642-1083352 [Salmonella sp. SJTUF14146]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4

Antitoxin

• AlphaFold DB: A0A822X3T2