Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1382731..1383351 Replicon chromosome
Accession NZ_CP049021
Organism Enterobacter hormaechei strain Eho-E3

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GVI75_RS06645 Protein ID WP_015571250.1
Coordinates 1382731..1382949 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GVI75_RS06650 Protein ID WP_006809850.1
Coordinates 1382977..1383351 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI75_RS06615 1378743..1379003 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
GVI75_RS06620 1379006..1379146 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GVI75_RS06625 1379143..1379853 - 711 WP_023303201.1 GNAT family N-acetyltransferase -
GVI75_RS06630 1379955..1381415 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
GVI75_RS06635 1381387..1381854 - 468 WP_017383209.1 membrane protein -
GVI75_RS06640 1381971..1382522 - 552 WP_023303203.1 maltose O-acetyltransferase -
GVI75_RS06645 1382731..1382949 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GVI75_RS06650 1382977..1383351 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GVI75_RS06655 1383862..1387008 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
GVI75_RS06660 1387031..1388224 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T150300 WP_015571250.1 NZ_CP049021:c1382949-1382731 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T150300 NZ_CP064671:2167699-2167802 [Salmonella sp. SJTUF14152]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT150300 WP_006809850.1 NZ_CP049021:c1383351-1382977 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT150300 NZ_CP064671:c2167804-2167659 [Salmonella sp. SJTUF14152]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References